Dongping Jiang
Purdue University
7 Papers
119 Citations
Dongping Jiang is an academic researcher from Purdue University. The author has contributed to research in topics: Adsorption & Hydroxide. The author has an hindex of 6, co-authored 6 publications.
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Papers
Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro
Garry L. Morefield,Anna Sokolovska,Dongping Jiang,Harm HogenEsch,J. Paul Robinson,Stanley L. Hem +5 more
TL;DR: It was concluded that antigen internalization by dendritic cells was enhanced when the antigen remained adsorbed to the aluminum-containing adjuvants following administration and the aggregate size of the adjuvant was smaller than dendrite cells which are approximately 10 microm in diameter.
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Effect of microenvironment pH of aluminum hydroxide adjuvant on the chemical stability of adsorbed antigen
TL;DR: The results suggest that the chemical stability of antigens that degrade by pH-dependent mechanisms can be optimized by modifying the surface charge of the aluminum-containing adjuvant to produce the pH of maximum stability in the microenvironment of the adjuant.
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Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid.
Garry L. Morefield,Dongping Jiang,Ilia Z. Romero-Mendez,Robert L. Geahlen,Harm HogenEsch,Stanley L. Hem +5 more
TL;DR: Adsorption of ovalbumin by aluminum-containing adjuvants and elution upon exposure to interstitial fluid can be controlled by the degree of phosphorylation of both ovalbum in and the aluminum- containing adjuvant.
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Structure and adsorption properties of commercial calcium phosphate adjuvant.
TL;DR: X-ray diffraction, FTIR spectroscopy, thermal analysis and the Ca/P molar ratio identify commercial calcium phosphate adjuvant as non-stoichiometric hydroxyapatite, Ca10-x (HPO4)x (PO4)6-X (OH)2-x, where x varies from 0 to 2.5.
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Relationship of adsorption mechanism of antigens by aluminum-containing adjuvants to in vitro elution in interstitial fluid
TL;DR: The results of this study lead to the generalization that antigens that adsorb to aluminum-containing adjuvants by electrostatic attraction are more likely to elute upon intramuscular or subcutaneous administration than antigen that adsorbed by ligand exchange.
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