Dongjun Lee
Harvard University
43 Papers
76 Citations
Dongjun Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 25 publications. Previous affiliations of Dongjun Lee include Pusan National University & KAIST.
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Papers
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes,Youmna Kfoury,Francois Mercier,Mathias Wawer,Jason M. Law,Mark K. Haynes,Timothy A. Lewis,Amir Schajnovitz,Esha Jain,Dongjun Lee,Hanna Meyer,Kerry A. Pierce,Nicola Tolliday,Anna Waller,Steven James Ferrara,Ashley Eheim,Detlef Stoeckigt,Katrina Maxcy,Julien Cobert,Jacqueline Bachand,Brian A. Szekely,Siddhartha Mukherjee,Larry A. Sklar,Joanne Kotz,Clary B. Clish,Ruslan I. Sadreyev,Paul A. Clemons,Andreas Janzer,Stuart L. Schreiber,David T. Scadden +29 more
TL;DR: The unanticipated discovery that inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) enables myeloid differentiation in human and mouse AML models demonstrates the role of DHODH as a metabolic regulator of differentiation and point to its inhibition as a strategy for overcoming differentiation blockade in AML.
430
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Dongjun Lee,Changwon Park,Ho Lee,Jesse J. Lugus,Seok Hyung Kim,Elizabeth Arentson,Yun Shin Chung,Gustavo Gomez,Michael Kyba,Shuo Lin,Ralf Janknecht,Dae-Sik Lim,Kyunghee Choi +12 more
TL;DR: It is shown that combined BMP, Notch, and Wnt signaling is necessary for efficient FLK1(+) mesoderm formation from embryonic stem cells (ESCs) andforced expression of ER71 in ESCs resulted in a robust induction of FLK 1(+) Mesoderm.
354
Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse
Sangphil Oh,Dongjun Lee,Tackhoon Kim,Tae Shin Kim,Hyun Jung Oh,Chae Young Hwang,Young-Yun Kong,Ki Sun Kwon,Dae-Sik Lim +8 more
TL;DR: Findings indicate that both Mst1 and Mst2 kinases play essential roles in early mouse development, regulating placental development, vascular patterning, primitive hematopoiesis, and cell proliferation and survival.
130
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Rushdia Z. Yusuf,Borja Saez,Azeem Sharda,Nick van Gastel,Vionnie W.C. Yu,Ninib Baryawno,Elizabeth W. Scadden,Sanket S. Acharya,Shrikanta Chattophadhyay,Cherrie Huang,Vasanthi Viswanathan,Dana S'aulis,Julien Cobert,David B. Sykes,Mark A. Keibler,Sudeshna Das,John N. Hutchinson,Michael Churchill,Siddhartha Mukherjee,Dongjun Lee,Francois Mercier,John G. Doench,Lars Bullinger,David J. Logan,Stuart L. Schreiber,Gregory Stephanopoulos,William B. Rizzo,David T. Scadden +27 more
TL;DR: Inhibiting Aldh3a2 provides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cells in acute myeloid leukemia.
93
Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence
Joonseok Cho,Rushdia Z. Yusuf,Sung-Ho Kook,Eyal C. Attar,Dongjun Lee,Bae-Hang Park,Tao Cheng,David T. Scadden,Byeong Chel Lee +8 more
TL;DR: It is demonstrated that P2Y14 modifies cell senescence and cell death in response to tissue stress, thereby enabling preservation of hematopoietic stem/progenitor cell function and suggested that P1Y14-mediated responses prevent the premature decline of regenerative capacity after injury.