Donghui Cao
Rutgers University
12 Papers
275 Citations
Donghui Cao is an academic researcher from Rutgers University. The author has contributed to research in topics: Receptor & Endoplasmic reticulum. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Donghui Cao include University of Medicine and Dentistry of New Jersey.
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Papers
Model of glycoprotein hormone receptor ligand binding and signaling.
William R. Moyle,Yongna Xing,Win Lin,Donghui Cao,Rebecca V. Myers,John E. Kerrigan,Michael P. Bernard +6 more
TL;DR: The region that links the lutropin receptor leucine-rich repeat domain (LRD) to its transmembrane domain (TMD) has substantial roles in ligand binding and signaling, hence the signaling specificity domain (SSD).
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Models of glycoprotein hormone receptor interaction.
TL;DR: Differences in the manners in which these ligands appear to interact with their receptors explain why some ligands and ligand analogs interact with more than one class of receptor and why some receptors and receptor analogs bind more thanOne ligand.
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Glycoprotein Hormone Assembly in the Endoplasmic Reticulum I. THE GLYCOSYLATED END OF HUMAN α-SUBUNIT LOOP 2 IS THREADED THROUGH A β-SUBUNIT HOLE
Yongna Xing,Rebecca V. Myers,Donghui Cao,Win Lin,Mei Jiang,Michael P. Bernard,William R. Moyle +6 more
TL;DR: It is suggested that the unusual structures of the glycoprotein hormones makes them useful for identifying factors that influence this process in living cells, and threading may be an important phenomenon during protein folding and macromolecule assembly in the endoplasmic reticulum.
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Glycoprotein Hormone Assembly in the Endoplasmic Reticulum: III. THE SEATBELT AND ITS LATCH SITE DETERMINE THE ASSEMBLY PATHWAY
Yongna Xing,Rebecca V. Myers,Donghui Cao,Win Lin,Mei Jiang,Michael P. Bernard,William R. Moyle +6 more
TL;DR: Wrapping the seatbelt latch site to the NH2-terminal end of the β-subunit would have facilitated teFSH assembly by a wraparound mechanism and may have contributed also to its ability to distinguish lutropin and follitropin receptors.
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Glycoprotein hormone assembly in the endoplasmic reticulum: IV. Probable mechanism of subunit docking and completion of assembly.
Yongna Xing,Rebecca V. Myers,Donghui Cao,Win Lin,Mei Jiang,Michael P. Bernard,William R. Moyle +6 more
TL;DR: In this article, it was shown that most human choriogonadotropin (hCG) is assembled by threading the glycosylated end of α-subunit loop 2 beneath the latched seatbelt rather than by wrapping the unlatched seatbelt around this loop.
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