Dong Kee Lee
Baylor College of Medicine
5 Papers
27 Citations
Dong Kee Lee is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Stromal cell & Estrogen. The author has an hindex of 5, co-authored 5 publications.
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Papers
Suppression of COUP-TFII by Proinflammatory Cytokines Contributes to the Pathogenesis of Endometriosis
Shih Chieh Lin,Yo Hua Li,Meng Hsing Wu,Yu Fan Chang,Dong Kee Lee,Sophia Y. Tsai,Ming-Jer Tsai,Shaw Jenq Tsai +7 more
TL;DR: The data demonstrate the critical function of proinflammatory cytokines and the COUP-TFII regulatory gene network in the progression of endometriosis.
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ERBB Receptor Feedback Inhibitor 1 Regulation of Estrogen Receptor Activity Is Critical for Uterine Implantation in Mice
TL;DR: The results identify a new signaling paradigm of steroid hormone regulation in female reproductive biology that adds insight into the underlying dysregulation of hormonal signaling in human reproductive disorders such as endometriosis and endometrial cancer.
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Critical tumor suppressor function mediated by epithelial mig-6 in endometrial cancer
Tae Hoon Kim,Dong Kee Lee,Sung Nam Cho,Grant D. Orvis,Richard R. Behringer,John P. Lydon,Bon Jeong Ku,Adrienne S. McCampbell,Russell Broaddus,Jae Wook Jeong,Jae Wook Jeong +10 more
TL;DR: It is established that epithelial Mig-6 functions as a critical tumor suppressor that mediates the ability of progesterone to prevent the development of endometrial cancer.
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Suppression of ERα Activity by COUP-TFII Is Essential for Successful Implantation and Decidualization
Dong Kee Lee,Isao Kurihara,Jae Wook Jeong,John P. Lydon,Francesco J. DeMayo,Ming-Jer Tsai,Sophia Y. Tsai +6 more
TL;DR: During the periimplantation period, COUP-TFII regulates embryo attachment and decidualization through controlling ERalpha activity, and shows a reduction of the expression of ERalpha target genes in PR(Cre/+);COUP- TFII(flox/flox) mutant mice, suggesting that the increased ER alpha activity is not the reason for placentation defects.
COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity.
Isao Kurihara,Dong Kee Lee,Fabrice G. Petit,Jae Wook Jeong,Kevin Y. Lee,John P. Lydon,Francesco J. DeMayo,Ming-Jer Tsai,Sophia Y. Tsai +8 more
TL;DR: A novel genetic pathway in which BMP2 lies downstream of COUP-TFII is identified, which provides a new signaling paradigm for steroid hormone regulation in female reproductive biology, with attendant implications for furthering the understanding of the molecular mechanisms that underlie dysregulation of hormonal signaling in such human reproductive disorders as endometriosis and endometrial cancer.