Dong Chen
University of Kentucky
10 Papers
45 Citations
Dong Chen is an academic researcher from University of Kentucky. The author has contributed to research in topics: Syntaxin & Exocytosis. The author has an hindex of 9, co-authored 10 publications. Previous affiliations of Dong Chen include University of California, Berkeley.
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Papers
Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 in dense core granule release
TL;DR: Immunoprecipitation studies showed that the 2 t-SNAREs syntaxin 2 and SNAP-23 do form a complex in vivo, which clearly show that SNAPs, NSF, and specific t- SNAREs are used for dense core granule release; these data provide a greater understanding of regulated exocytosis in platelets.
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SNAP-23 requirement for transferrin recycling in Streptolysin-O-permeabilized Madin-Darby canine kidney cells.
TL;DR: Observations suggest that SNAP-23 may be required for fusion of recycling vesicles with the basolateral membrane of polarized MDCK cells.
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Intracellular localization of SNAP-23 to endosomal compartments.
Dong Chen,Sidney W. Whiteheart +1 more
TL;DR: Investigation of the intracellular localization of the ubiquitously expressed target membrane SNAP receptor (t-SNARE), SNAP-23 shows that it has a punctate, perinuclear localization in HepG2 and HT4 cells, consistent with a role for Snapchat in both endosome-plasma membrane trafficking as well as endosomesome-endosome transport.
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Gaf-1, a γ-SNAP-binding Protein Associated with the Mitochondria
TL;DR: A two-hybrid screen was used to identify new, γ-SNAP-binding proteins and to uncover potentially novel functions for γ -SNAP, pointing to a potential role for the ubiquitously expressed protein in mitochondrial dynamics.
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