Donald M. O'Rourke
University of Pennsylvania
217 Papers
1.3K Citations
Donald M. O'Rourke is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 50, co-authored 187 publications. Previous affiliations of Donald M. O'Rourke include Hospital of the University of Pennsylvania & Drexel University.
Chat about Author
Papers
Pattern Analysis of Dynamic Susceptibility Contrast-enhanced MR Imaging Demonstrates Peritumoral Tissue Heterogeneity
Hamed Akbari,Luke Macyszyn,Xiao Da,Ronald L. Wolf,Michel Bilello,Ragini Verma,Donald M. O'Rourke,Christos Davatzikos +7 more
TL;DR: Analysis of dynamic susceptibility contrast-enhanced MR imaging data by using principal component analysis can help identify imaging variables that can be subsequently used to evaluate the peritumoral region in glioblastoma.
Glioblastoma: The Current State of Biology and Therapeutic Strategies.
Zev A. Binder,Donald M. O'Rourke +1 more
TL;DR: It is believed specialized academic centers that form meaningful corporate partnerships to complement basic science infrastructure and use adaptive clinical trial designs will achieve more rapid translation of innovative approaches to glioblastoma.
Transcriptome signatures associated with meningioma progression
Angela N. Viaene,Angela N. Viaene,Bo Zhang,Maria Martinez-Lage,Maria Martinez-Lage,Chaomei Xiang,Chaomei Xiang,Umberto Tosi,Jayesh P. Thawani,Busra Gungor,Yuankun Zhu,Laura Roccograndi,Logan Zhang,Robert L. Bailey,Robert L. Bailey,Phillip B. Storm,Donald M. O'Rourke,Adam C. Resnick,M. Sean Grady,Nadia Dahmane,Nadia Dahmane +20 more
TL;DR: Bioinformatic analyses showed that grade I meningiomas that progress to a higher grade are molecularly different from those that do not, and this study identifies GREM2, a regulator of the BMP pathway, and the snoRNAs SNORA46 andSNORA48, as being significantly reduced inMeningioma progression.
Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma
Sumei Wang,Donald M. O'Rourke,Sanjeev Chawla,Gaurav Verma,MacLean Nasrallah,Jennifer J.D. Morrissette,Gabriela Plesa,Carl H. June,Steven Brem,Eileen Maloney,Arati Desai,Ronald L. Wolf,Harish Poptani,Harish Poptani,Suyash Mohan +14 more
TL;DR: It is indicated that multiparametric MRI may be helpful in monitoring CAR-T related early therapeutic changes in GBM patients.
Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy
TL;DR: Tremendous efforts are currently ongoing to identify novel CAR targets and target combinations for glioblastoma, to modify T cells to enhance their efficacy and to enable them to resist tumor-mediated immunosuppression, and to utilize adjunct therapies such as lymphodepletion, checkpoint inhibition, and bi-specific engagers to improve CAR T persistence.