Donald M. O'Rourke
University of Pennsylvania
217 Papers
1.3K Citations
Donald M. O'Rourke is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 50, co-authored 187 publications. Previous affiliations of Donald M. O'Rourke include Hospital of the University of Pennsylvania & Drexel University.
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Papers
A prospective validation cohort study of baseline plasma cell-free DNA (cfDNA) as a prognostic biomarker in newly diagnosed glioblastoma (GBM).
Stephen J Bagley,Seyed Ali Nabavizadeh,Jacob Till,Aseel Abdalla,Hareena Sanga,Jazmine Mays,Timothy Prior,Andrew Jurgielewicz,Samantha Guiry,Karapet Davtyan,Stephanie S. Yee,Zev A. Binder,Donald M. O'Rourke,Steven Brem,Arati Desai,Erica L. Carpenter +15 more
TL;DR: Novel prognostic biomarkers are needed to determine the prognosticImpairment outcomes in patients with GBM, and a novel approach is needed to assess the importance of heterogeneity in the selection of these biomarkers.
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Abstract B139: Toxicity testing of EGFRvIII CAR-based immunotherapy of glioblastoma: From bench to bedside
Alexandria P. Cogdill,Alina C. Boesteanu,Chong Xu,Kathleen A. Haines,John Scholler,Joseph A. Fraietta,Yangbing Zhao,Xiaojun Liu,Jennifer J.D. Morrissette,Bruce L. Levine,Simon F. Lacey,Andreas Loew,Reshma Singh,Jennifer Brogdon,Donald M. O'Rourke,Marcela V. Maus,Carl H. June,Laura A. Johnson +17 more
TL;DR: A panel of donor-derived primary cells are generated and expanded ex-vivo in to sufficient numbers to utilize as targets for evaluating potential normal tissue toxicity of epidermal growth factor receptor mutation variant three (EGFRvIII)-specific chimeric antigen receptors (CAR) prior to use in clinical trials for patients with glioblastoma.
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Nimg-33. prognostic stratification of de novo glioblastoma patients across 22 geographically distinct institutions: updates from the respond consortium
Hamed Akbari,Spyridon Bakas,Chiharu Sako,Anahita Fathi Kazerooni,Javier Villanueva-Meyer,José Aznarez García,Stephen J Bagley,Ujjwal Baid,Michel Bilello,Steven Brem,Robert H. Lustig,Suyash Mohan,MacLean Nasrallah,Donald M. O'Rourke,R. Calabrese,Jeffrey D. Rudie,Pamela LaMontagne,Daniel S. Marcus,Carmen Balana,Jaume Capellades,Josep Puig,Jill S. Barnholtz-Sloan,Chaitra Badve,Andrew E. Sloan,Murat Ak,Rivka R. Colen,Sung Soo Ahn,Jong Hee Chang,Yoon Seong Choi,Seung Koo Lee,Adam P. Dicker,Adam E. Flanders,Wenyin Shi,Gaurav Shukla,Brent Griffith,Laila M. Poisson,Lisa Rogers,Thomas C. Booth,Rajan Jain,Matthew D. Lee,Abhishek Mahajan,Arnab Chakravarti,Joshua D. Palmer,William J. Taylor,Santiago Cepeda,Benedikt Wiestler,Christos Davatzikos +46 more
TL;DR: In this paper , the authors proposed an AI-based prognosis for diffuse glioblastoma (IDH-wildtype)/NOS/-NEC patients from 22 geographically distinct institutions across 3 continents, with preoperative structural MRI scans.