Donald F. Hunt
University of Virginia
396 Papers
6.2K Citations
Donald F. Hunt is an academic researcher from University of Virginia. The author has contributed to research in topics: Peptide sequence & Mass spectrometry. The author has an hindex of 109, co-authored 391 publications. Previous affiliations of Donald F. Hunt include University of Birmingham & University of California, San Diego.
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Papers
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.
David J. Mitchell,Kiev R. Blasier,Erin D. Jeffery,Mitchell W. Ross,Ashok K. Pullikuth,Dong Suo,Jin Ho Park,W. R. Smiley,Kevin W.-H. Lo,Jeffrey Shabanowitz,Christopher D. Deppmann,Jonathan C. Trinidad,Donald F. Hunt,Andrew D. Catling,K. Kevin Pfister +14 more
TL;DR: Results demonstrate that neurotrophin binding to Trk initiates the recruitment of cytoplasmic dynein to signaling endosomes through ERK1/2 phosphorylation of intermediate chains for their subsequent retrograde transport in axons.
MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Mark Cobbold,Mark Cobbold,Hugo De La Peña,Andrew Norris,Joy M. Polefrone,Jie Qian,Ann M. English,Kara L. Cummings,Sarah A Penny,James E. Turner,Jennifer Cottine,Jennifer G. Abelin,Stacy A. Malaker,Angela L. Zarling,Hsing-Wen Huang,Oliver Goodyear,Sylvie D. Freeman,Jeffrey Shabanowitz,Guy Pratt,Charles Craddock,Charles Craddock,Michael E. Williams,Donald F. Hunt,Victor H. Engelhard +23 more
TL;DR: The results suggest that phosphopeptides may be targets of cancer immune surveillance in humans, and point to their importance for development of vaccine-based and T cell adoptive transfer immunotherapies.
Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1
Carla M. Abreu,Ramesh Kumar,Danielle Hamilton,Andrew William Dawdy,Kevin Creavin,Sarah Eivers,Karen Finn,Jeremy L. Balsbaugh,Rosemary O'Connor,Patrick A. Kiely,Jeffrey Shabanowitz,Donald F. Hunt,Muriel Grenon,Noel F. Lowndes +13 more
TL;DR: It is shown that cell cycle phosphorylation of the prototypical DDR mediator Saccharomyces cerevisiae Rad9 depends on cyclin-dependent kinase (CDK) complexes, and a specific G2/M form of Cdc28 can phosphorylate in vitro the N-terminal region of Rad9 on nine consensus CDK phosphorylated sites.
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
Thurl E. Harris,Todd A. Huffman,An Chi,Jeffrey Shabanowitz,Donald F. Hunt,Anil Kumar,John C. Lawrence +6 more
TL;DR: The results suggest that insulin and epinephrine control lipin primarily by changing localization rather than intrinsic PAP activity.
Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes
Qinghui Hu,Carthene R. Bazemore Walker,Cristina Girao,Joseph T. Opferman,Jiling Sun,J. Shabanowitz,Donald F. Hunt,Philip G. Ashton-Rickardt +7 more
TL;DR: It is demonstrated that abundant self-peptides, purified from the H-2D(b) molecules of thymic epithelial cells, are specifically recognized during the positive selection of CD8+ T cells, implying that positive selection generates a repertoire of T cells that is weakly self-reactive.