Donald C. Lo

TL;DR: In this paper, the authors proposed to use drug repurposing screens to identify effective synergistic drug candidates for emerging and re-emerging viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS)-CoV, Ebola, Zika, and SARS-CORONAVirus 2 (CoV-2).

TL;DR: In this article, the authors carried out a quantitative high-throughput screen using a SARS-CoV-2 cytopathic assay with a compound collection of 8,810 approved and investigational drugs, mechanism-based bioactive compounds, and natural products.

TL;DR: In this article, the authors evaluated six lysosomotropic compounds to identify an alternative Lysosome-based drug repurposing opportunity and found that six of these compounds blocked the cytopathic effect of SARS-CoV-2.

TL;DR: Application of iPSC-derived human neurons is a new direction for neuronal drug discovery because these cells have the genetic backgrounds of patients that more precisely model disease-specific pathophysiology and phenotypes.