Dominique Larrey
French Institute of Health and Medical Research
378 Papers
4K Citations
Dominique Larrey is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Hepatitis. The author has an hindex of 62, co-authored 363 publications.
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Papers
Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening
Vlad Ratziu,Vlad Ratziu,Stephen A. Harrison,Sven Francque,Pierre Bedossa,Philippe Lehert,Philippe Lehert,Lawrence Serfaty,Manuel Romero-Gómez,Jérôme Boursier,Manal F. Abdelmalek,Steve Caldwell,Joost P.H. Drenth,Quentin M. Anstee,Dean W. Hum,Rémy Hanf,A. Roudot,S. Megnien,Bart Staels,Arun J. Sanyal,Philippe Mathurin,J. Gournay,Eric Nguyen-Khac,V. de Ledinghen,Dominique Larrey,A. Tran,M. Bourliere,M. Maynard-Muet,Tarik Asselah,Jean Henrion,Frederik Nevens,David Cassiman,Albert Geerts,Christophe Moreno,Ulrich Beuers,Peter R. Galle,Ulrich Spengler,Elisabetta Bugianesi,Antonio Craxì,Mario Angelico,Silvia Fargion,M. Voiculescu,Liana Gheorghe,L. Preotescu,Juan Caballería,Raúl J. Andrade,Javier Crespo,J. L. Callera,Aftab Ala,Guruprasad P. Aithal,G. Abouda,Velimir A. Luketic,M. A. Huang,Stuart C. Gordon,Paul J. Pockros,Fred Poordad,N. Shores,M. W. Moehlen,Kiran Bambha,V. Clark,Sanjaya K. Satapathy,S. Parekh,R. K. Reddy,Muhammad Y. Sheikh,Gyongyi Szabo,John M. Vierling,T. Foster,Guillermo E. Umpierrez,C. Chang,Terry Box,J. Gallegos-Orozco +70 more
TL;DR: A post-hoc analysis of data from trial of patients with NASH showed that elafibranor (120 mg/d for 1 year) resolved NASH without fibrosis worsening, based on a modified definition, in the intention-to-treat analysis and in patients with moderate or severe NASH.
952
Case definition and phenotype standardization in drug-induced liver injury
Guruprasad P. Aithal,Paul B. Watkins,Raúl J. Andrade,Dominique Larrey,Mariam Molokhia,Hajime Takikawa,Christine M. Hunt,Russell A. Wilke,Mark I. Avigan,Neil Kaplowitz,Einar Björnsson,Ann K. Daly +11 more
TL;DR: An international DILI Expert Working Group of clinicians and scientists reviewed current DILi terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute D ILI.
942
EASL Clinical Practice Guidelines: Drug-induced liver injury
Raúl J. Andrade,Guruprasad P. Aithal,Einar Björnsson,Neil Kaplowitz,Gerd A. Kullak-Ublick,Dominique Larrey,Tom H. Karlsen +6 more
TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.
842
Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study
Fabrice Carrat,Hélène Fontaine,Céline Dorival,Mélanie Simony,Alpha Diallo,Christophe Hézode,Victor de Ledinghen,Dominique Larrey,Georges Haour,Jean-Pierre Bronowicki,Fabien Zoulim,Tarik Asselah,Patrick Marcellin,Dominique Thabut,Vincent Leroy,Albert Tran,François Habersetzer,Didier Samuel,Dominique Guyader,Olivier Chazouillères,Philippe Mathurin,Sophie Metivier,Laurent Alric,Ghassan Riachi,Jérôme Gournay,Armand Abergel,Paul Calès,Nathalie Ganne,Véronique Loustaud-Ratti,Louis d’Alteroche,Xavier Causse,Claire Geist,Anne Minello,Isabelle Rosa,Moana Gelu-Simeon,Isabelle Portal,François Raffi,Marc Bourlière,Stanislas Pol +38 more
TL;DR: Treatment with direct-acting antivirals is associated with reduced risk for mortality and hepatocellular carcinoma and should be considered in all patients with chronic HCV infection.
550
Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications
Pierre Nahon,Pierre Nahon,Valérie Bourcier,Richard Layese,Etienne Audureau,Carole Cagnot,Patrick Marcellin,Dominique Guyader,Hélène Fontaine,Dominique Larrey,Victor de Ledinghen,Denis Ouzan,Fabien Zoulim,Dominique Roulot,Albert Tran,Jean-Pierre Bronowicki,Jean-Pierre Zarski,Vincent Leroy,Ghassan Riachi,Paul Calès,Jean-Marie Péron,Laurent Alric,Marc Bourlière,Philippe Mathurin,Sébastien Dharancy,Jean-Frédéric Blanc,Armand Abergel,Lawrence Serfaty,Ariane Mallat,Jean-Didier Grangé,Pierre Attali,Yannick Bacq,Claire Wartelle,Thong Dao,Yves Benhamou,Christophe Pilette,Christine Silvain,Christos Christidis,Dominique Capron,Brigitte Bernard-Chabert,David Zucman,Vincent Di Martino,Vincent Thibaut,Dominique Salmon,Marianne Ziol,Angela Sutton,Stanislas Pol,Françoise Roudot-Thoraval,Gérard Thiéfin,Sophie Hillaire +49 more
TL;DR: A reduction in critical events, liver-related or not, was confirmed in the CirVir cohort, a prospective study of patients with HCV infection and compensated cirrhosis included in the ANRS cohort who achieved an SVR, to reduce overall mortality and risk of death from liver- related and non-liver-related causes.
517