抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with the ability to be stretched, compressed, twisted, bent, and deformed into arbitrary shapes. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we review these strategies and describe applications of them in systems ranging from electronic eyeball cameras to deformable light-emitting displays. We conclude with some perspectives on routes to commercialization, new device opportunities, and remaining challenges for research.

http://science.sciencemag.org/content/sci/327/5973/1603.full.pdf

Materials and mechanics for stretchable electronics

Structure and nanostructure in ionic liquids.

Untethered small-scale (from several millimetres down to a few micrometres in all dimensions) robots that can non-invasively access confined, enclosed spaces may enable applications in microfactories such as the construction of tissue scaffolds by robotic assembly, in bioengineering such as single-cell manipulation and biosensing, and in healthcare such as targeted drug delivery and minimally invasive surgery. Existing small-scale robots, however, have very limited mobility because they are unable to negotiate obstacles and changes in texture or material in unstructured environments. Of these small-scale robots, soft robots have greater potential to realize high mobility via multimodal locomotion, because such machines have higher degrees of freedom than their rigid counterparts. Here we demonstrate magneto-elastic soft millimetre-scale robots that can swim inside and on the surface of liquids, climb liquid menisci, roll and walk on solid surfaces, jump over obstacles, and crawl within narrow tunnels. These robots can transit reversibly between different liquid and solid terrains, as well as switch between locomotive modes. They can additionally execute pick-and-place and cargo-release tasks. We also present theoretical models to explain how the robots move. Like the large-scale robots that can be used to study locomotion, these soft small-scale robots could be used to study soft-bodied locomotion produced by small organisms.

Small-scale soft-bodied robot with multimodal locomotion

We consider the inertia-dominated rise of a meniscus around a vertical circular cylinder. Previous experiments and scaling analysis suggest that the height of the meniscus, $h_{m}$
 , grows with the time following the initiation of rise, $t$
 , like $h_{m}\propto t^{1/2}$
 . This is in contrast to the rise on a vertical plate, which obeys the classic capillary–inertia scaling $h_{m}\propto t^{2/3}$
 . We highlight a subtlety in the scaling analysis that yielded $h_{m}\propto t^{1/2}$
 and investigate the consequences of this subtlety. We develop a potential flow model of the dynamic problem, which we solve using the finite element method. Our numerical results agree well with previous experiments but suggest that the correct early time behaviour is, in fact, $h_{m}\propto t^{2/3}$
 . Furthermore, we show that at intermediate times the dynamic rise of the meniscus is governed by two parameters: the contact angle and the cylinder radius measured relative to the capillary length scale, $t^{2/3}$
 . This result allows us to collapse previous experimental results with different cylinder radii (but similar static contact angles) onto a single master curve.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/EB794F5A76219887DC5D41CCC3E72B7B/S0022112015000890a.pdf/div-class-title-inertial-rise-of-a-meniscus-on-a-vertical-cylinder-div.pdf

Inertial rise of a meniscus on a vertical cylinder

We investigate impact of a sphere onto a floating elastic sheet and the resulting formation and evolution of wrinkles in the sheet. Following impact, we observe a radially propagating wave, beyond which the sheet remains approximately planar but is decorated by a series of radial wrinkles whose wavelength grows in time. We develop a mathematical model to describe these phenomena by exploiting the asymptotic limit in which the bending stiffness is small compared to stresses in the sheet. The results of this analysis show that, at a time t after impact, the transverse wave is located at a radial distance r∼t1/2 from the impactor, in contrast to the classic r∼t2/3 scaling observed for capillary–inertia ripples produced by dropping a stone into a pond. We describe the shape of this wave, starting from the simplest case of a point impactor, but subsequently addressing a finite-radius spherical impactor, contrasting this case with the classic Wagner theory of impact. We show also that the coarsening of wrinkles in the flat portion of the sheet is controlled by the inertia of the underlying liquid: short-wavelength, small-amplitude wrinkles form at early times since they accommodate the geometrically imposed compression without significantly displacing the underlying liquid. As time progresses, the liquid accelerates and the wrinkles grow larger and coarsen. We explain this coarsening quantitatively using numerical simulations and scaling arguments, and we compare our predictions with experimental data.

/pdf/impact-on-floating-thin-elastic-sheets-a-mathematical-model-2ikjyir0wg.pdf

Impact on floating thin elastic sheets: A mathematical model

Nanopores made with low-dimensional semiconducting materials, such as carbon nanotubes and graphene slit pores, are used in supercapacitors. For modelling purposes, it is often assumed that such pores screen ion-ion interactions like metallic pores, i.e. that screening leads to an exponential decay of the interaction potential with ion separation. By introducing a quantum capacitance that accounts for the density of states in the material, we show that ion-ion interactions in carbon nanotubes and graphene slit pores actually decay algebraically with ion separation. This result suggests a new avenue of capacitance optimization based on tuning the electronic structure of a pore: a marked enhancement in capacitance might be achieved by developing nanopores made with metallic materials or bulk semimetallic materials.

https://iopscience.iop.org/article/10.1209/0295-5075/113/38005/pdf

Quantum Capacitance Modifies Interionic Interactions in Semiconducting Nanopores

The designers of mobile robots often take their inspiration from animals. In recent years, examples have included SmartBird, a flying robot that is modeled on a herring gull; BigDog, a rough-terrain robot that can walk, run, climb, and carry heavy loads; and the humanoid Asimo. With the exception of SmartBird, however, these robots can only move horizontally and over land. Being able to cope with different terrains remains a key challenge for robotics. Perhaps no two terrains are more different than land and water, and yet several animals can move equally well on either ( 1 ). On page 517 of this issue, Koh et al. describe a robot that is so at home on the water surface that it can leap to heights of 14 cm without piercing the surface ( 2 ).

https://science.sciencemag.org/content/sci/349/6247/472.full.pdf

Two leaps forward for robot locomotion

We study the dynamics of MEMS microbeams undergoing electrostatic pull-in. At DC voltages close to the pull-in voltage, experiments and numerical simulations have reported `bottleneck' behaviour in which the transient dynamics slow down considerably. This slowing down is highly sensitive to external forces, and so has widespread potential for applications that use pull-in time as a sensing mechanism, including high-resolution accelerometers and pressure sensors. Previously, the bottleneck phenomenon has only been understood using lumped mass-spring models that do not account for effects such as variable residual stress and different boundary conditions. We extend these studies to incorporate the beam geometry, developing an asymptotic method to analyse the pull-in dynamics. We attribute bottleneck behaviour to critical slowing down near the pull-in transition, and we obtain a simple expression for the pull-in time in terms of the beam parameters and external damping coefficient. This expression is found to agree well with previous experiments and numerical simulations that incorporate more realistic models of squeeze film damping, and so provides a useful design rule for sensing applications. We also consider the accuracy of a single-mode approximation of the microbeam equations --- an approach that is commonly used to make analytical progress, without systematic investigation of its accuracy. By comparing to our bottleneck analysis, we identify the factors that control the error of this approach, and we demonstrate that this error can indeed be very small.

https://iopscience.iop.org/article/10.1088/1361-6439/aad72f/pdf

Pull-in dynamics of overdamped microbeams

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