Dominic P. Kwiatkowski
Wellcome Trust Sanger Institute
465 Papers
3.8K Citations
Dominic P. Kwiatkowski is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Malaria. The author has an hindex of 100, co-authored 441 publications. Previous affiliations of Dominic P. Kwiatkowski include Medical Research Council & Wellcome Trust Centre for Human Genetics.
Chat about Author
Papers
The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype
Gavin Band,Gavin Band,Ellen M. Leffler,Ellen M. Leffler,Muminatou Jallow,Fatoumatta Sisay-Joof,Carolyne M. Ndila,Alexander Macharia,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Thuy Nguyen,Sónia Gonçalves,Cristina V. Ariani,Jim Stalker,Richard D. Pearson,Richard D. Pearson,Roberto Amato,Eleanor Drury,Giorgio Sirugo,Umberto D'Alessandro,Kalifa Bojang,Kevin Marsh,Kevin Marsh,Norbert Peshu,David J. Conway,Thomas N. Williams,Thomas N. Williams,Kirk A. Rockett,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +32 more
TL;DR: This article investigated the correlation between host and parasite genetic variation in 4,171 Gambian and Kenya children ascertained with severe malaria due to Plasmodium falciparum.
Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa.
Gaia Luoni,Federica Verra,Bruno Arcà,B S Sirima,Marita Troye-Blomberg,Mario Coluzzi,Dominic P. Kwiatkowski,David Modiano,David Modiano +8 more
TL;DR: It is reported that anti-malarial antibody levels show a wide distribution amongst the Fulani themselves, raising the possibility that quantitative analysis within the Fulali may be an efficient way of screening for important genetic factors.
Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia
Alfred Amambua-Ngwa,David Jeffries,Roberto Amato,Archibald Worwui,Mane Karim,Sukai Ceesay,Haddy Nyang,Davis Nwakanma,Joseph Okebe,Dominic P. Kwiatkowski,David J. Conway,Umberto D'Alessandro +11 more
TL;DR: Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in 2008 and 2014 were analysed to identify changes possibly related to the scale-up of antimalarial interventions that occurred during this period.
Extreme mutation bias and high AT content in Plasmodium falciparum
William L Hamilton,William L Hamilton,Antoine Claessens,Antoine Claessens,Antoine Claessens,Thomas D. Otto,Mihir Kekre,Rick M. Fairhurst,Julian C. Rayner,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +10 more
TL;DR: High AT content in P. falciparum is driven by a systematic mutational bias and ultimately leads to an unusual level of microstructural plasticity, raising the question of whether this contributes to adaptive evolution.
Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.
Christophe Aucan,Andrew Walley,Branwen J. Hennig,J Fitness,Angela J. Frodsham,Lyna Zhang,Dominic P. Kwiatkowski,A V S Hill +7 more
TL;DR: A role for the type I interferon pathway in resistance to cerebral malaria is suggested in malaria pathogenesis and protection against severe malaria.