Dominic C. Mills
University of London
19 Papers
18 Citations
Dominic C. Mills is an academic researcher from University of London. The author has contributed to research in topics: Campylobacter jejuni & Glycan. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Dominic C. Mills include Cornell University & University of Alberta.
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Papers
Campylobacter jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial Cells
A Elmi,Eleanor Watson,Pamela Sandu,Ozan Gundogdu,Dominic C. Mills,Neil F. Inglis,Erin D. T. Manson,Lisa Imrie,Mona Bajaj-Elliott,Brendan W. Wren,David Smith,Nick Dorrell +11 more
TL;DR: C. jejuni OMVs possess cytotoxic activity and induce a host immune response from T84 intestinal epithelial cells (IECs), which was not reduced by OMV pretreatment with proteinase K or polymyxin B prior to coincubation with IECs, suggesting OMV induction of IL-8 is independent of CDT.
Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis.
Jon Cuccui,Rebecca M. Thomas,Madeleine G. Moule,Riccardo V. D'Elia,Thomas R. Laws,Dominic C. Mills,Diane Williamson,Timothy P. Atkins,Timothy P. Atkins,Joann L. Prior,Brendan W. Wren +10 more
TL;DR: The application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant glycoconjugate vaccine is described and the conjugation of the Francisella tularensis O-antigen to the Pseudomonas aeruginosa carrier protein exotoxin A is demonstrated.
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Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design.
Vanessa S. Terra,Dominic C. Mills,Laura E. Yates,Sherif Abouelhadid,Jon Cuccui,Brendan W. Wren +5 more
TL;DR: Recent technical developments in this area are highlighted, including the first structural determination of the coupling enzyme PglB, the use of glycotags for optimal glycan attachment and the possible applications of other glycosylation systems and how these may improve and extend PGCT.
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Bacterial Glycoengineering as a Biosynthetic Route to Customized Glycomolecules.
TL;DR: This chapter highlights some of the key discoveries and technologies for equipping bacteria with the requisite biosynthetic machinery to generate a range of glycomolecules produced recombinantly in bacterial systems.
Vibrio cholerae accessory colonisation factor AcfC: a chemotactic protein with a role in hyperinfectivity
Esmeralda Valiente,Cadi Davies,Dominic C. Mills,Dominic C. Mills,María Getino,Jennifer M. Ritchie,Brendan W. Wren +6 more
TL;DR: The findings suggest that AcfC contributes to the chemotactic response of WT V. cholerae and plays an important role in defining the overall distribution of the organism within the intestine.