Domenico Ribatti
University of Bari
965 Papers
6.1K Citations
Domenico Ribatti is an academic researcher from University of Bari. The author has contributed to research in topics: Angiogenesis & Biology. The author has an hindex of 96, co-authored 913 publications. Previous affiliations of Domenico Ribatti include University of Genoa & National Institutes of Health.
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Papers
Cancer associated fibroblasts in hematological malignancies
TL;DR: The involvement of CAFs in progression of hematological malignancies and the potential targeting ofCAFs in a therapeutic perspective are discussed.
Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma
Angelo Vacca,Claudio Scavelli,Guido Serini,Giulia Di Pietro,Teresa Cirulli,Francesca Merchionne,Domenico Ribatti,Federico Bussolino,Diego Guidolin,Giovanna Piaggio,Andrea Bacigalupo,Franco Dammacco +11 more
TL;DR: By counteracting VEGF165 activity as efficiently as an anti-VEGFR-2 antibody, exogenous SEMA3A restrains the over-angiogenic potential of MMECs and could be responsible for the angiogenic switch from MGUS to MM.
Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2.
TL;DR: This study confirms that leptin is angiogenic in vivo and suggests that, at least in the chick CAM, its activity is in part mediated by the activation of endogenous FGF-2.
ALK-Dependent Control of Hypoxia-Inducible Factors Mediates Tumor Growth and Metastasis
Cinzia Martinengo,Teresa Poggio,Matteo Menotti,Maria Stella Scalzo,Cristina Mastini,Chiara Ambrogio,Elisa Pellegrino,Ludovica Riera,Roberto Piva,Domenico Ribatti,Fabio Pastorino,Patrizia Perri,Mirco Ponzoni,Qi Wang,Claudia Voena,Roberto Chiarle +15 more
TL;DR: AnALK-specific regulation of the hypoxia response across different ALK(+) tumor types is uncovered and HIFs are proposed as a powerful specific therapeutic target in ALK-rearranged ALCL and NSCLC.
Role of Endothelial Cells and Fibroblasts in Multiple Myeloma Angiogenic Switch.
TL;DR: Microenvironmental factors induce MMECs and fibroblasts to become functionally different from monoclonal gammopathy of undetermined significance, and be similar to transformed cells, which play an important role in MM progression and may represent new molecular markers for prognostic stratification of patients and prediction of response to antiangiogenic drugs.