Do-Kyun Kim
National Institutes of Health
21 Papers
28 Citations
Do-Kyun Kim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chemistry & Mast cell. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Do-Kyun Kim include Konkuk University.
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Papers
Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol-Inducible Cytochrome P450-2E1-Mediated Oxidative and Nitrative Stress.
TL;DR: It is shown that fructose intake causes protein nitration of intestinal TJ and AJ proteins, resulting in increased gut leakiness, endotoxemia, and steatohepatitis with liver fibrosis, at least partly, through a CYP2E1‐dependent manner.
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Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice.
Jin-hyeon Hwang,Yu Seong Park,Hyuk-Soon Kim,Dong-ha Kim,Sang-Hoon Lee,Chan-Hyeong Lee,Seung-Hoon Lee,Jung-Eun Kim,Sangkyu Lee,Ho Min Kim,Hyun Woo Kim,Jihoon Kim,Wonhyo Seo,Hyo-Jung Kwon,Byoung Joon Song,Do-Kyun Kim,Moon-Chang Baek,Young-Eun Cho +17 more
TL;DR: In this article , the beneficial effects of yam-derived exosome-like nanovesicles (YNVs) on promoting differentiation and mineralization of osteoblasts for bone regeneration in ovariectomized (OVX)-induced osteoporotic mice were successfully isolated and characterized.
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Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation.
Do-Kyun Kim,Geethani Bandara,Young-Eun Cho,Hirsh D. Komarow,Danielle R. Donahue,Baktiar Karim,Moon-Chang Baek,Ho Min Kim,Dean D. Metcalfe,Ana Olivera +9 more
TL;DR: It is found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with SM (SM-EVs) block osteoblast differentiation and mineralization in culture, and when injected into mice diminish the expression of osteOBlast markers, and trabecular bone volume and microarchitecture.
Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice.
Young-Eun Cho,Wonhyo Seo,Do-Kyun Kim,Pyong-Gon Moon,Sang-Hyun Kim,Byung-Heon Lee,Byoung-Joon Song,Moon-Chang Baek +7 more
TL;DR: It is demonstrated that exogenous exosomes from APAP-exposed mice with acute liver injury are functional and stimulate cell death or toxicity of the recipient hepatocytes and mice.
Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis.
Rosa Muñoz-Cano,Rosa Muñoz-Cano,Mariona Pascal,Joan Bartra,César Picado,Antonio Valero,Do-Kyun Kim,Stephen R. Brooks,Michael J. Ombrello,Dean D. Metcalfe,Juan Rivera,Ana Olivera +11 more
TL;DR: Gene ontology analysis suggests disturbances in gut epithelial homeostasis in both groups with LTP-A, with potential integrity breaches in patients with L TP-A that might explain their distinct inflammatory signatures.
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