Dmitry Stakheev
Charles University in Prague
10 Papers
32 Citations
Dmitry Stakheev is an academic researcher from Charles University in Prague. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 4, co-authored 10 publications. Previous affiliations of Dmitry Stakheev include Academy of Sciences of the Czech Republic.
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Papers
The WNT/β-catenin signaling inhibitor XAV939 enhances the elimination of LNCaP and PC-3 prostate cancer cells by prostate cancer patient lymphocytes in vitro.
Dmitry Stakheev,Pavla Taborska,Zuzana Strizova,Michal Podrazil,Jirina Bartunkova,Daniel Smrz +5 more
TL;DR: It was found that 5 µM XAV939 inhibited β-catenin translocation to the nucleus in LNCaP cells and CD4+ BRPCa lymphocytes without affecting their proliferation and viability.
IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions
Gianluca Mucciolo,Claudia Curcio,Cecilia Roux,Wanda Y. Li,Michela Capello,Roberta Curto,Roberto Chiarle,Roberto Chiarle,Daniele Giordano,Maria Antonietta Satolli,Rita T. Lawlor,Aldo Scarpa,Pavol Lukáč,Dmitry Stakheev,Dmitry Stakheev,Paolo Provero,Luca Vannucci,Tak W. Mak,Francesco Novelli,Paola Cappello +19 more
TL;DR: In this paper, the role of interleukin-17A (IL17A) and its effect on tumor fibroblasts and the tumor microenvironment was investigated in pancreatic ductal adenocarcinoma (PDA) mice.
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NK and T cells with a cytotoxic/migratory phenotype accumulate in peritumoral tissue of patients with clear cell renal carcinoma.
Zuzana Strizova,Pavla Taborska,Dmitry Stakheev,Simona Partlova,Klara Havlova,S. Vesely,Jirina Bartunkova,Daniel Smrz +7 more
TL;DR: The cytotoxic/migratory lymphocytes were identified in tumors of Renal cell carcinoma patients and revealed that the peritumoral tissue of ccRCC patients is a reservoir of TRAIL+FasL+, TRAIL-1+, or FasL+PECAM-1+ NK and T cells.
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Personalized ex vivo multiple peptide enrichment and detection of T cells reactive to multiple tumor-associated antigens in prostate cancer patients
Pavla Taborska,Dmitry Stakheev,Zuzana Strizova,Katerina Vavrova,Michal Podrazil,Jirina Bartunkova,Daniel Smrz +6 more
TL;DR: The strategy revealed that the personalized multiple peptide-mediated ex vivo enrichment with multiple TAAs-reactive T cells in the PCa patient’s lymphocytes is a viable approach for development of T cell immunotherapy of PCa.
13
CD4 + T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein.
TL;DR: It is shown that CD4+ T cells of SARS-CoV-2-unexposed patients with hormone-refractory (HR) metastatic PCa had decreased CD4+, but not from the spiked glycoprotein of the ‘common cold’-associated human coronavirus 229E (H coV-229E), highlighting the potential for increased vulnerability of PCa patients to COVID-19.