DM Knight
University of Bristol
11 Papers
87 Citations
DM Knight is an academic researcher from University of Bristol. The author has contributed to research in topics: Biology & Matrix (biology). The author has an hindex of 7, co-authored 11 publications.
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Papers
Identification of an immune-responsive mesolimbocortical serotonergic system: Potential role in regulation of emotional behavior
Christopher A. Lowry,Jacob Harvey Hollis,A. de Vries,B. Pan,Laura Rosa Brunet,Jon R. F. Hunt,Julian F. R. Paton,E. van Kampen,DM Knight,Andrea Evans,Graham A. W. Rook,Stafford L. Lightman +11 more
TL;DR: The findings suggest that the immune-responsive subpopulation of serotonergic neurons in the DRI is likely to play an important role in the neural mechanisms underlying regulation of the physiological and pathophysiological responses to both acute and chronic immune activation, including regulation of mood during health and disease states.
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Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system.
TL;DR: A tetracycline-regulatable adenoviral transfection system that mediates efficient long-term transfer of genes into neuronal cells in vivo and should be of value in behavioral studies and in vivo studies of neuronal gene function, and may further the development of effective gene therapy strategies in the brain.
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The HSP90 Molecular Chaperone Cycle Regulates Cyclical Transcriptional Dynamics of the Glucocorticoid Receptor and Its Coregulatory Molecules CBP/p300 During Ultradian Ligand Treatment
Becky L. Conway-Campbell,Charlotte L. George,John R. Pooley,DM Knight,Michael R. Norman,Gordon L. Hager,Stafford L. Lightman +6 more
TL;DR: HSP90 regulates cyclical glucocorticoid receptor activity, cofactor recruitment, histone acetylation and transcriptional pulsing at the Period 1 promoter in response to ultradian glucoc Corticoid exposure.
Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activity
Francesca Spiga,Louise R Harrison,SA Wood,DM Knight,Cliona P MacSweeney,Fiona Thomson,Mark Craighead,Stafford L. Lightman +7 more
TL;DR: The results confirm that this compound is an antagonist of the V(1b)R in the rat, and that its ability to reduce stress-induced ACTH responses is stressor dependent with differential modulation of pituitary and adrenal responses.
Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding
Francesca Spiga,DM Knight,Susanne K. Droste,Becky L. Conway-Campbell,YM Kershaw,Cliona P MacSweeney,Fiona Thomson,Mark Craighead,Bernard W. M. M. Peeters,Stafford L. Lightman +9 more
TL;DR: Findings reveal differential effects of RU486 and S-P on areas involved in regulation of hypothalamic–pituitary–adrenal axis activity in vivo and they are important in light of the potential use of this class of compounds in the treatment of disorders associated with hyperactivity of the hypothalamic-pituitaries-adrenals axis.
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