Divya Raj
University Medical Center Groningen
13 Papers
2 Citations
Divya Raj is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Divya Raj include University of Groningen & Utrecht University.
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Papers
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Inge R. Holtman,Divya Raj,Jeremy A. Miller,Wandert Schaafsma,Zhuoran Yin,Nieske Brouwer,Paul D. Wes,Thomas Möller,Marie Orre,Willem Kamphuis,Elly M. Hol,Elly M. Hol,Elly M. Hol,Erik Boddeke,Bart J. L. Eggen +14 more
TL;DR: Microglia priming induces a highly conserved transcriptional signature with aging- and disease-specific aspects that prominently differed from the acute inflammatory gene network induced by lipopolysaccharide (LPS).
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
Zhuoran Yin,Divya Raj,Nasrin Saiepour,Debby Van Dam,Nieske Brouwer,Inge R. Holtman,Bart J. L. Eggen,Thomas Möller,Joseph A. Tamm,Aicha Abdourahman,Elly M. Hol,Elly M. Hol,Elly M. Hol,Willem Kamphuis,Thomas A. Bayer,Peter Paul De Deyn,Erik Boddeke +16 more
TL;DR: Evidence is provided that Aβ plaque-associated microglia are hyperreactive in their immune response and phagocytosis in the transgenic AD mice as well as in EOAD brain tissue.
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Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening
Divya Raj,Jill Moser,Susanne M. A. van der Pol,Ronald van Os,Inge R. Holtman,Nieske Brouwer,Hisko Oeseburg,Wandert Schaafsma,Evelyn Wesseling,Wilfred F. A. den Dunnen,Knut Biber,Knut Biber,Helga E. de Vries,Bart J. L. Eggen,Hendrikus Boddeke +14 more
TL;DR: The increased inflammatory response in microglia correlates closely with increased peripheral inflammation, a loss of blood–brain barrier integrity, and infiltration of immune cells in the brain parenchyma in this mouse model of telomere shortening.
An optimized protocol for the acute isolation of human microglia from autopsy brain samples
Marta Olah,Divya Raj,Nieske Brouwer,Alexander H. De Haas,Bart J. L. Eggen,Wilfred F. A. den Dunnen,Knut Biber,Hendrikus Boddeke +7 more
TL;DR: The procedure presented in this article enables acute isolation of human microglia from autopsy (and biopsy) samples with a purity and yield that is suitable for downstream applications, such as protein and gene expression analysis and functional assays.
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