Disha Joshi
University of Pittsburgh
5 Papers
Disha Joshi is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
Engineered tRNAs suppress nonsense mutations in cells and in vivo
Suki Albers,Elizabeth Allen,Nikhil Bharti,Marcos Davyt,Disha Joshi,Carlos G. Perez-Garcia,Leonardo A. Santos,Rajesh Mukthavaram,Brandon Molina,Kristen Kuakini,Maher Alayyoubi,Kyoung-Joo Jenny Park,Grishma Acharya,Jose A. Gonzalez,Amit Sagi,Susan E. Birket,Guillermo J. Tearney,Steven M. Rowe,Candela Manfredi,Jeong S. Hong,Kiyoshi Tachikawa,Priya Prakash Karmali,Daiki Matsuda,Eric J. Sorscher,Padmanabh Chivukula,Zoya Ignatova +25 more
TL;DR: In this paper , a strategy based on altering native tRNAs into efficient suppressor tRNA (sup-tRNAs) by individually fine-tuning their sequence to the physico-chemical properties of the amino acid that they carry was proposed.
Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts
Regina Rab,Annette Ehrhardt,Bhagelu R. Achyut,Disha Joshi,Melissa Gilbert-Ross,Chunzi Huang,Katharine Floyd,Anton V. Borovjagin,William Parker,Eric J. Sorscher,Jeong S. Hong +10 more
TL;DR: These studies provide the scientific foundation necessary to improve PNP prodrug cleavage and advance a new treatment for head and neck cancer.
2
606 Focused clinical trials of modulator response for rare cystic fibrosis genotypes
G. Solomon,Shingo Suzuki,Heather Hathorne,Cristina Barillà,B. Wang,A. Rab,Candela Manfredi,Disha Joshi,John J. Brewington,Arlene A. Stecenko,W. Driggers,S. Bai,Elizabeth Hunter,A. Streby,J. Hong,Katherine Odem-Davis,Brian R. Davis,Eric J. Sorscher,R. Linnemann +18 more
Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics
Minsoo Kim,Eli Fritz McDonald,Carleen M. Sabusap,Bibek Timalsina,Disha Joshi,Jeong S. Hong,Andras Rab,Eric J. Sorscher,Lars Plate +8 more
TL;DR: In this paper , the authors investigated the underlying cellular mechanisms of how CFTR biogenesis is altered by correctors in these variants and provided a better understanding of VX-445 biological mechanism of action and reveal cellular targets that may sensitize unresponsive CFTR variants to known and available correctors.
NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Jennifer L. Gregg,Robert M. Turner,Guimin Chang,Disha Joshi,Ye Zhan,Li Chen,Jodi K. Maranchie +6 more
TL;DR: It is reported that NOX4 silencing in VHL-deficient RCC cells abrogates cell branching, invasion, colony formation, and growth in a murine xenograft model RCC.