Dirk Theile
Heidelberg University
65 Papers
318 Citations
Dirk Theile is an academic researcher from Heidelberg University. The author has contributed to research in topics: Pregnane X receptor & Chemistry. The author has an hindex of 15, co-authored 52 publications. Previous affiliations of Dirk Theile include University Hospital Heidelberg.
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Papers
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein
TL;DR: This is the first study to provide comprehensive information on the P- gp interaction profile of anti-HIV drugs under identical assay conditions and reveals that many compounds may indeed inhibit P-gp substantially and indicates that of the various systems tested, the calcein assay in P388/dx/P388 cells is the most suitable and reliable in vitro model for the quantification of P-GP inhibition.
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Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy
TL;DR: The results obtained indicate that both down- and up-regulations of drug transporters could favour synergistic action of this drug combination, and proposes as one mechanism the 5-FU mediated suppression of ATP7B, the over-expression of glutathione exporters such as MRP2/ABCC2 and the decrease of glutATHione levels by oxalate.
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The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters
Juan Pablo Rigalli,Guillermo Nicolás Tocchetti,Maite Rocío Arana,Silvina Stella Maris Villanueva,Viviana A. Catania,Dirk Theile,María Laura Ruiz,Johanna Weiss +7 more
TL;DR: Potential nutrient-drug interactions that could threaten chemotherapy efficacy, especially in ABCG2-expressing tumors treated with substrates of this transporter are suggested.
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Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells
Johanna Weiss,Dirk Theile,Adriana Spalwisz,Jürgen Burhenne,Klaus-Dieter Riedel,Walter E. Haefeli +5 more
TL;DR: It is demonstrated that although sildenafil and tadalafil indeed reduce intracellular concentrations of bosentan and ambrisentan in LS180 cells, they do not mitigate the inducing effects of these endothelin-1 receptor antagonists.
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In-vitro evaluation of chronic alcohol effects on expression of drug-metabolizing and drug-transporting proteins.
TL;DR: In alcoholics without alcoholic liver disease, boosted drug elimination has been reported, but mechanistic explanations for this phenomenon remain uncertain and data on the potential role of drug transporters are sparse.
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