Dirk Behrens
University of Kiel
5 Papers
75 Citations
Dirk Behrens is an academic researcher from University of Kiel. The author has contributed to research in topics: Antigen & MHC class I. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Dirk Behrens include Corixa Corporation.
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Papers
Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination.
TL;DR: Peptide 56–80 appears to represent a dominant epitope that can be exploited for establishing tolerance in this transplantation strain combination, and is interesting that residue alignment of peptide 56-80 to the motif of the RT1.A1 molecule showed a preferred class I motif within this sequence, suggesting indirect presentation of this peptide to recipient T cells.
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Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model.
Dirk Behrens,Katrin Lange,Ari J. Fried,Kyoung-Ae Yoo-Ott,Kathrin Richter,Fred Fändrich,M. Krönke,Nicholas Zavazava +7 more
TL;DR: In this paper, the authors reported that repetitive intraperitoneal injection of recombinant Lewis rat-derived MHC class I antigens in DA rats modulates alloreactivity.
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A divalent human leukocyte antigen-B7 fusion-protein up-regulates CD25 and CD69 in alloreactive CD8+ T cells bypassing CD28 costimulation.
TL;DR: The dichotomy in T-cell regulation by a divalent MHC fusion protein warrants the use of MHC multimers as custom-designed immune-regulatory molecules both in transplantation and autoimmune disease.
6
Allogeneic recombinant soluble MHC class I molecules modify urinary odor cues in rats
TL;DR: It is shown that injected recombinant soluble MHC class I molecules temporarily alter urine odor of Lewis test rats and this change in urinary signals is caused by quantitative changes of at least two nitrogen-containing urinary compounds.
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