Dipti Rai
Utrecht University
6 Papers
Dipti Rai is an academic researcher from Utrecht University. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 3, co-authored 3 publications.
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Papers
Feedback-Driven Assembly of the Axon Initial Segment.
Amélie Fréal,Amélie Fréal,Dipti Rai,Roderick P. Tas,Xingxiu Pan,Eugene A. Katrukha,Dieudonnée van de Willige,Riccardo Stucchi,Amol Aher,Chao Yang,A. F. Maarten Altelaar,Karin Vocking,Jan A. Post,Martin Harterink,Lukas C. Kapitein,Anna Akhmanova,Casper C. Hoogenraad,Casper C. Hoogenraad +17 more
TL;DR: This study reveals feedback-based mechanisms driving AIS assembly, and shows that Ankyrin-G acts as a scaffold interacting with End-Binding proteins and membrane proteins such as Neurofascin-186 to recruit TRIM46-positive microtubules to the plasma membrane.
70
CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
Amol Aher,Dipti Rai,Laura Schaedel,Jérémie Gaillard,Karin John,Qingyang Liu,Maarten Altelaar,Laurent Blanchoin,Laurent Blanchoin,Manuel Théry,Manuel Théry,Anna Akhmanova +11 more
TL;DR: In vitro reconstitution assays combined with laser microsurgery and microfluidics were used to show that CLASP2α indeed stimulates microtubule lattice repair and promotes tubulin incorporation into damaged lattice sites, thereby restoring microtubules integrity.
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Compressive forces stabilize microtubules in living cells
Yuhui Li,Ondřej Kučera,Damien Cuvelier,David M. Rutkowski,Mathieu Deygas,Dipti Rai,Tonja Pavlovič,Filipe Nunes Vicente,Matthieu Piel,Grégory Giannone,Dimitrios Vavylonis,Anna Akhmanova,Laurent Blanchoin,Manuel Théry +13 more
TL;DR: These results demonstrate that microtubules in living cells have mechano-responsive properties that allow them to resist and even counteract the forces to which they are subjected.
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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC
Dipti Rai,Yinlong Song,Shasha Hua,Kelly Stecker,Jooske Louise Monster,Victor Yin,Riccardo Stucchi,Yixin Xu,Yaqian Zhang,Fangrui Chen,Eugene A. Katrukha,Marteen Altelaar,Albert J. R. Heck,Michal Wieczorek,Kai Jiang,Anna Akhmanova +15 more
TL;DR: CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC, with CAMSAP2 and CAMSAP3 inducing release, while CDK5RAP2 suppresses CAMSAP binding and promotes γ-TuRC-dependent nucleation, influencing microtubule structure and organization.
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CAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors
Dipti Rai,Shasha Hua,Jooske Louise Monster,Riccardo Stucchi,Kelly Stecker,Yaqian Zhang,Eugene A. Katrukha,Maarten Altelaar,Michal Wieczorek,Kai Jiang,Anna Akhmanova +10 more
TL;DR: The results support a model whereby CAMSAPs exploit an imperfect attachment between γ-TuRC and the nucleated microtubule to promote minus-end elongation and release, whereas CDK5RAP2 improves the fit betweenγ- TuRC and 13-protofilament microtubules and enhances nucleation.