Diptendu Ghosh
Chittaranjan National Cancer Institute
11 Papers
60 Citations
Diptendu Ghosh is an academic researcher from Chittaranjan National Cancer Institute. The author has contributed to research in topics: Downregulation and upregulation & Immune system. The author has an hindex of 8, co-authored 10 publications.
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Papers
Pretreatment with neem (Azadirachta indica) leaf preparation in swiss mice diminishes leukopenia and enhances the antitumor activity of cyclophosphamide
TL;DR: NLP would be an effective tool to reduce CYP‐induced hematological complications and in vitro tumor cell cytotoxicity by peripheral blood mononuclear cells from CYP treated mice in either normal or tumor bearing conditions.
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Neem leaf glycoprotein inhibits CD4+CD25+Foxp3+ Tregs to restrict murine tumor growth.
Tathagata Chakraborty,Anamika Bose,Subhasis Barik,Kuntal Kanti Goswami,Saptak Banerjee,Shyamal Goswami,Diptendu Ghosh,Soumyabrata Roy,Krishnendu Chakraborty,Koustav Sarkar,Rathindranath Baral +10 more
TL;DR: The possibility of NLGP being an excellent tool as a T-cell anergy breaker by abrogating the suppressor functions of Tregs in cancer needs to be explored further in the clinic.
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Interferon α2b augments suppressed immune functions in tobacco-related head and neck squamous cell carcinoma patients by modulating cytokine signaling
Anamika Bose,Diptendu Ghosh,Smarajit Pal,Kalyan Kusum Mukherjee,Jaydip Biswas,Rathindranath Baral +5 more
TL;DR: It is concluded that IFNalpha2b may be effective as a tool for adjuvant therapy along with conventional therapies to overcome the immunosuppression in HNSCC patients.
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Induction of type 1 cytokines during neem leaf glycoprotein assisted carcinoembryonic antigen vaccination is associated with nitric oxide production.
Koustav Sarkar,Anamika Bose,Enamul Haque,Krishnendu Chakraborty,Tathagata Chakraborty,Shyamal Goswami,Diptendu Ghosh,Rathindranath Baral +7 more
TL;DR: Results clearly demonstrated the interdependence of two anti-tumor immune functions, namely, NO production and generation of type 1 immune response.
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Neem (Azadirachta indica) leaf preparation prevents leukocyte apoptosis mediated by cisplatin plus 5-fluorouracil treatment in Swiss mice.
TL;DR: Significant down-regulation of leukocyte apoptosis was noted in mice pretreated with NLP or granulocyte colony stimulating factor (GCSF) during cis + 5-FU therapy, suggesting enhanced cytotoxicity may be associated with N LP-induced increase of the cytotoxic T and NK cell pool.
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