Dingkun Gui
Shanghai Jiao Tong University
19 Papers
52 Citations
Dingkun Gui is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 7 publications.
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Papers
Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats.
TL;DR: The protective effect of AS-IV on ER stress-induced podocyte apoptosis is associated with inhibition of PERK-ATF4-CHOP pathway, which may be a novel strategy for the treatment of DN.
Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways
TL;DR: Astragaloside IV (AS-IV) can be developed as a novel therapeutic approach to prevent AKI through targeting inhibition of oxidative stress and apoptosis pathways.
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Emodin ameliorates high glucose induced-podocyte epithelial-mesenchymal transition in-vitro and in-vivo.
TL;DR: EMO ameliorated glucose-induced EMT and subsequent podocyte dysfunction partly through ILK and desmin inhibition as well as nephrin upregulatiotion, which might provide a potential novel therapeutic option for DKD.
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway
Yadi Liu,Zhongyan Sun,Ruixue Dong,Peiyu Liu,Xi Zhang,Yiran Li,Xiaoshan Lai,Hio-Fai Cheong,Yuwei Wu,Yilin Wang,Hua Zhou,Dingkun Gui,Youhua Xu +12 more
TL;DR: In in vitro and in vivo models of diabetic NAFLD, Rutin alleviated lipid accumulation, inflammation, and oxidative stress and might be a potential new drug ingredient for diabetic NAFLD.
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Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats
TL;DR: The results suggest that AS-IV might be developed as a novel therapeutic approach to prevent ischemic AKI through inhibition of NF-κB mediated inflammatory genes expression.