21 Papers
259 Citations
Ding Chen is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Fusion protein & Antibody. The author has an hindex of 15, co-authored 19 publications.
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Papers
Intracellular Interleukin-1α Mediates Interleukin-8 Production Induced by Chlamydia trachomatis Infection via a Mechanism Independent of Type I Interleukin-1 Receptor
TL;DR: It is demonstrated that the proinflammatory cytokine interleukin-1 α (IL-1α) plays an essential role in chlamydial induction of the chemokine IL-8 and that expression of a transgene-encoded full-length IL-1β fusion protein in the nuclei enhanced IL- 8 production.
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Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Zhiwei Huang,Yingcai Feng,Ding Chen,Xiaojing Wu,Siyang Huang,Xiaojun Wang,Xing-Guo Xiao,Wenhui Li,Niu Huang,Lichuan Gu,Guangming Zhong,Jijie Chai +11 more
TL;DR: The activation mechanism of the CPAF serine protease is revealed and new opportunities for anti-Chlamydia drug development are suggested.
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Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice
TL;DR: It is demonstrated that immunization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge.
Identifying Catalytic Residues in CPAF, a Chlamydia-Secreted Protease
TL;DR: A computational approach to search the protein databank for structures that are compatible with the CPAF amino acid sequence reveals that CPAf possesses a fold similar to that of the catalytic domains of the tricorn protease from Thermoplasma acidophilum, and thatCPAF residues H105, S499, and E558 are structurally analogous to the trICORN protease catalytic triad residues.
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Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells.
TL;DR: It is demonstrated that CPAF undergoes autoprocessing and self-activation during chlamydial infection.
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