Dina Daitchman
Weizmann Institute of Science
4 Papers
1 Citations
Dina Daitchman is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: PIN1 & Cancer. The author has an hindex of 2, co-authored 4 publications.
Chat about Author
Papers
Diffusion of ring-shaped proteins along DNA: case study of sliding clamps.
TL;DR: In this article, the authors explored the linear diffusion of four ring-shaped proteins of very similar structure: three sliding clamps (PCNA, β-clamp, and gp45) and the 9-1-1 protein, with a particular focus on PCNA.
Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?
TL;DR: The proposed spiral cog-wheel mechanism, where the clamp keeps a fixed orientation relative to the DNA, as the main component for PCNA diffusion along DNA, is not supported by the authors' work and the diffraction data do not support the reported location of the DNA.
Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine
Benika J. Pinch,Zainab M. Doctor,Christopher M. Browne,Hyuk-Soo Seo,Behnam Nabet,Shingo Kozono,Xiaolan Lian,Daniel Zaidman,Dina Daitchman,Nir London,Lu Gong,Theresa D. Manz,Yujin Chun,Li Tan,Jarrod A. Marto,Stephen Buratowski,Sirano Dhe-Paganon,Xiao Zhou,Kun Ping Lu,Nathanael S. Gray +19 more
TL;DR: A highly potent, cell-permeable Pin1 inhibitor that covalently targets Cys113, a conserved cysteine residue in the Pin1 active site, and it is demonstrated that Pin1 inhibition represents a tractable strategy in PDAC.
1
Identification of a potent and selective covalent Pin1 inhibitor.
Benika J. Pinch,Zainab M. Doctor,Behnam Nabet,Christopher M. Browne,Christopher M. Browne,Hyuk-Soo Seo,Mikaela L. Mohardt,Shingo Kozono,Xiaolan Lian,Theresa D. Manz,Theresa D. Manz,Yujin Chun,Shin Kibe,Daniel Zaidman,Dina Daitchman,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Li Tan,Scott B. Ficarro,Nir London,Jarrod A. Marto,Jarrod A. Marto,Stephen Buratowski,Sirano Dhe-Paganon,Xiao Zhen Zhou,Kun Ping Lu,Nathanael S. Gray +27 more
TL;DR: A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis / trans isomerase NIMA-interacting 1 (Pin1) is used to show thatPin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation and that Pin1 inhibition impairs cell viability over time in PDAC cell lines.