Dimitra Vyrla
University of Crete
7 Papers
29 Citations
Dimitra Vyrla is an academic researcher from University of Crete. The author has contributed to research in topics: MAP kinase kinase kinase & Genetic enhancement. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Dimitra Vyrla include Foundation for Research & Technology – Hellas.
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Papers
Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer
TL;DR: Recent epidemiologic, clinicopathologic, and mechanistic studies investigating the role of ApoA-I in cancer biology suggest that enhancing the tumor suppressive activity of Apa-I may contribute to better cancer prevention and treatment.
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TPL2 kinase is a suppressor of lung carcinogenesis
Katerina Gkirtzimanaki,Kalliopi Gkouskou,Urszula Oleksiewicz,Georgios Nikolaidis,Dimitra Vyrla,Michalis Liontos,Vasiliki Pelekanou,Dimitris C. Kanellis,Kostantinos Evangelou,Efstathios N. Stathopoulos,John K. Field,Philip N. Tsichlis,Vassilis G. Gorgoulis,Triantafillos Liloglou,Aristides G. Eliopoulos +14 more
TL;DR: Tumor Progression Locus 2 (TPL2), a kinase implicated in the regulation of innate and adaptive immune responses, fulfils a role as a suppressor of lung carcinogenesis and is subject to diverse genetic and epigenetic aberrations in lung cancer patients.
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Neorogioltriol and Related Diterpenes from the Red Alga Laurencia Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses
Maria Daskalaki,Dimitra Vyrla,Maria Harizani,Christina Doxaki,Aristides G. Eliopoulos,Vassilios Roussis,Efstathia Ioannou,Christos Tsatsanis,Sotirios C. Kampranis,Sotirios C. Kampranis +9 more
TL;DR: Treatment of mice with 2 or 3 suppressed DSS-induced colitis by reducing tissue damage and pro-inflammatory cytokine production and all these three diterpenes are promising lead molecules for the development of anti-inflammatory agents targeting macrophage polarization mechanisms.
30
Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand
Lina Liljenfeldt,Katerina Gkirtzimanaki,Dimitra Vyrla,Emma Svensson,Angelica Loskog,Aristides G. Eliopoulos +5 more
TL;DR: Assessment of the combined effect of local RAd-CD40L and 5-fluorouracil (5-FU) administration on a syngeneic MB49 mouse bladder tumor model suggests that R adenovirus-mediated CD40L gene therapy is a promising adjuvant treatment to 5-FU for the management of bladder cancer.
20
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury
Dimitra Vyrla,Georgios Nikolaidis,Fiona Oakley,Maria J. Perugorria,Philip N. Tsichlis,Derek A. Mann,Aristides G. Eliopoulos,Aristides G. Eliopoulos +7 more
TL;DR: It is demonstrated that TPL2, an MAP3 kinase that has mostly been appreciated for its physiological role in macrophage responses, is a signaling factor in CD3+NK1.1+ iNKT cells and mediator of hepatic inflammation.
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