Dilara Grate

TL;DR: Quantification of CLB2 expression at the RNA and protein levels by RT-PCR and Western blot analysis demonstrates that the aptamer ligand regulates transcript translatability rather than stability, consistent with a model in which translational initiation is blocked by ligand-induced conformational changes in the 5'-UTR.

TL;DR: In this paper, the nucleic acid sensor molecules recognize target molecules which do not naturally bind to DNA by binding a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties, which leads to a change of the optical properties of the NAs on the biosensor.

TL;DR: In this article, a method for using nucleic acid therapeutics in the treatment of complement-related disorders is described. But this method is not suitable for the use in the medical field.

TL;DR: In this paper, materials and methods for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PD GF receptor, VEGF, and VEGFs receptor or any combination thereof with great affinity and specificity are provided.