Diego A. Espinoza
University of Pennsylvania
23 Papers
49 Citations
Diego A. Espinoza is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 8, co-authored 19 publications. Previous affiliations of Diego A. Espinoza include National Institutes of Health & Johns Hopkins University School of Medicine.
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Papers
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.
Sokratis A. Apostolidis,Mihir Kakara,Mark M Painter,Rishi R. Goel,Divij Mathew,Kerry Lenzi,Ayman Rezk,Kristina R. Patterson,Diego A. Espinoza,Jessy C. Kadri,Daniel M. Markowitz,Clyde E. Markowitz,Ina Mexhitaj,Dina A. Jacobs,Allison Babb,Michael R. Betts,Eline T. Luning Prak,Daniela Weiskopf,Alba Grifoni,Kendall A. Lundgreen,Sigrid Gouma,Alessandro Sette,Alessandro Sette,Paul Bates,Scott E. Hensley,Allison R. Greenplate,E. John Wherry,Rui Li,Amit Bar-Or +28 more
TL;DR: In this article, an anti-CD20 monoclonal antibody (aCD20) was used to reduce spike-specific and receptor-binding domain (RBD)-specific antibody and memory B cell responses in most patients.
Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.
Chuanfeng Wu,Diego A. Espinoza,Samson J. Koelle,E. Lake Potter,Rong Lu,Brian Li,Di Yang,Di Yang,Xing Fan,Robert E. Donahue,Mario Roederer,Cynthia E. Dunbar +11 more
TL;DR: Notably, local BM production of CD3+ T cells early after transplantation is documented, suggesting a thymus-independent T cell developmental pathway operating during BM regeneration, perhaps before thymic recovery.
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
Marcus A.F. Corat,Marcus A.F. Corat,Heinrich Schlums,Chuanfeng Wu,Jakob Theorell,Diego A. Espinoza,Stephanie Sellers,Danielle M. Townsley,Neal S. Young,Yenan T. Bryceson,Yenan T. Bryceson,Cynthia E. Dunbar,Thomas Winkler +12 more
TL;DR: The findings support the existence of a long-lived, adaptive NK-cell population maintained independently from GPIposCD56dim, and these adaptive NK cells were similar in PNH patients and healthy individuals.
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Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
Idalia M. Yabe,Idalia M. Yabe,Lauren L. Truitt,Diego A. Espinoza,Chuanfeng Wu,Samson J. Koelle,Samson J. Koelle,Sandhya R. Panch,Marcus A.F. Corat,Marcus A.F. Corat,Thomas Winkler,Kyung-Rok Yu,So Gun Hong,Aylin C. Bonifacino,Allen E. Krouse,Mark E. Metzger,Robert E. Donahue,Cynthia E. Dunbar +17 more
TL;DR: Analysis of clonal output from thousands of individual HSPCs transduced with these barcoded vectors revealed sustained clonal diversity, with no progressive dominance of clones containing any of the three vectors for up to almost 3 years post-transplantation, which support a low genotoxic risk for lentivirus vectors in H SPCs, even those containing strong promoters and/or enhancers.
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SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load
Erin L. Buchanan,Diego A. Espinoza,Melissa A. McAlexander,Stephanie L. Myers,Adam L. Moyer,Kenneth W. Witwer +5 more
TL;DR: In vitro, SAMHD1 transcript was abundant in macaque astrocytes and further induced by Type I interferon, while IFN produced a weaker response in the more permissive environment of the macrophage, which cannot rule out a contribution of SAM HD1 to retroviral restriction in relatively non-permissive CNS cell types.