Diane Luo
8 Papers
Diane Luo is an academic researcher. The author has contributed to research in topics: Biology & DNA methylation. The author has an hindex of 2, co-authored 4 publications.
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Papers
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
Kevin C. Johnson,Kevin J. Anderson,Elise T. Courtois,Amit D. Gujar,Floris P. Barthel,Frederick S. Varn,Diane Luo,Martine Seignon,Eun Hee Yi,Hoon Kim,Marcos R. Estecio,Dacheng Zhao,Ming Tang,Nicholas Navin,Rahul Maurya,Chew Yee Ngan,Niels Verburg,Philip C. De Witt Hamer,Ketan R. Bulsara,Michael Samuels,Sunit Das,Paul Robson,Roel G.W. Verhaak +22 more
TL;DR: Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance as mentioned in this paper, which highlights the importance of epigenetic heterogeneity in shaping therapeutic outcomes and identifies a positive association between genetic and epigenetic instability that was supported in bulk longitudinally collected DNA methylation data.
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Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues.
Elise T. Courtois,Yuliana Tan,William F. Flynn,Santosh Sivajothi,Diane Luo,Suleyman Bozal,Anthony A. Luciano,Paul Robson,Danielle E. Luciano +8 more
TL;DR: A holistic view of the endometriosis microenvironment representing the first comprehensive cell atlas of the disease is provided, essential information for advancing therapeutics and diagnostics is provided.
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Author Correction: Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues
Yuliana Tan,William F. Flynn,Santhosh Sivajothi,Diane Luo,Suleyman Bozal,Monica Davé,Anthony A. Luciano,Paul Robson,Danielle E. Luciano,Elise T. Courtois +9 more
TL;DR: (Tfeb) mice appearing in the left and center columns were switched and micrographs shown in the right column were mistakenly rotated, and the micrograph matching WT cells treated with LLOMe at the 3 hr time point was mistakenly shown.
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Immunosuppressive tumor microenvironment of osteosarcoma
Aaron M. Taylor,Patrick Kwok Shing Ng,Jeffrey M Harder,Parveen Kumar,Alissa M. Dzis,Nathaniel L. Jillette,Andrew Goodspeed,Avery Bodlak,Qian Wu,Michael S. Isakoff,Joshy George,Jessica D.S. Grassmann,Diane Luo,William F. Flynn,Elise T. Courtois,Paul Robson,Masanori Hayashi,Alini Trujillo Paulillo,Silvia Regina Caminada de Toledo,Fabiola Sara Balarezo,Adam D. Lindsay,Bang Hoang,Ching C. Lau +22 more
TL;DR: Using single-cell transcriptomics, the presence of multiple immunosuppressive cell subtypes of neutrophils, T-cells, and dendritic cells is discovered in osteosarcoma patients.
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Abstract P1-24-04: Spatially resolved cell type heterogeneity uncovers the distinct biology of inflammatory breast cancer
Elise T. Courtois,William J. Flynn,Santhosh Sivajothi,Martine Seignon,Diane Luo,Bora Lim,Paul Robson +6 more
TL;DR: Spatially resolved cell type heterogeneity uncovers the distinct biology of inflammatory breast cancer as well as identifying the cellular composition surrounding the tumor microemboli.