Diane Bartley
7 Papers
31 Citations
Diane Bartley is an academic researcher. The author has contributed to research in topics: Phosphorylation & Mass spectrometry. The author has an hindex of 6, co-authored 7 publications.
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Papers
Structural Characterization of a Soluble Amyloid β-Peptide Oligomer
Liping Yu,Rohinton Edalji,John E. Harlan,Thomas F. Holzman,Ana Pereda Lopez,Boris Labkovsky,Heinz Hillen,Stefan Barghorn,Ulrich Ebert,Paul L. Richardson,Laura J. Miesbauer,Larry R. Solomon,Diane Bartley,Karl A. Walter,Robert W. Johnson,Philip J. Hajduk,Edward T. Olejniczak +16 more
TL;DR: Using NMR, the NMR data indicate that soluble oligomers of Abeta preglobulomer and globulomer have a mixed parallel and antiparallel beta-sheet structure that is different from fibrils which contain only parallel beta-sheets.
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Toxicological evaluation of thiol-reactive compounds identified using a la assay to detect reactive molecules by nuclear magnetic resonance.
Jeffrey R. Huth,Danying Song,Renaldo Mendoza,Candice L. Black-Schaefer,Jamey Mack,Sarah A. Dorwin,Uri S. Ladror,Jean M. Severin,Karl A. Walter,Diane Bartley,Philip J. Hajduk +10 more
TL;DR: ALARM NMR seems to be a sensitive tool to rapidly identify compounds with an enhanced risk of producing side effects in humans, including alcohol intolerance, the formation of reactive oxygen species, and drug-drug interactions.
79
A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase
Karen Kage,Paul L. Richardson,Linda Traphagen,Jean M. Severin,Ana Pereda-Lopez,Thomas H. Lubben,Rachel Davis-Taber,Melissa H. Vos,Diane Bartley,Karl A. Walter,John E. Harlan,Larry R. Solomon,Usha Warrior,Thomas F. Holzman,Connie R. Faltynek,Carol S. Surowy,Victoria E. Scott +16 more
TL;DR: D-AMC can be successfully used to rapidly and effectively identify novel FAAH inhibitors for potential therapeutic use, and is demonstrated to offer improved sensitivity and accuracy over previously reported endpoint assays.
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Characterization of protein kinase A phosphorylation: multi-technique approach to phosphate mapping.
Jianwei Shen,Richard A. Smith,Vincent S. Stoll,Rohinton Edalji,Clarissa G. Jakob,Karl A. Walter,Emily Gramling,Sally Dorwin,Diane Bartley,Angelo Gunasekera,Jianguo Yang,Thomas F. Holzman,Robert W. Johnson +12 more
TL;DR: Data from this study suggested that PKA was completely phosphorylated at S10, T197, and S338 and partially phosphorylations at S139, illustrating that critical information can be lost unless multiple MS techniques are used for identification and validation of phosphorylation.
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P2-483: Biophysical characterization of soluble amyloid-β peptide oligomers
Edward T. Olejniczak,Liping Yu,Rohinton Edalji,John E. Harlan,Thomas F. Holzman,Ana Perada Lopez,Boris Labkovsky,Heinz Hillen,Stefan Barghorn,Ulrich Ebert,Paul L. Richardson,Laura Miesbauer,Larry R. Solomon,Diane Bartley,Karl A. Walter,Robert E. Johnson,Philip J. Hajduk +16 more
TL;DR: The rational design approach using de novo design software SPROUT has successfully delivered a new cellular active BACE1 inhibitor scaffold using an optimised lead to the inhibitor structure.
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