Diana Risin
Wyle Laboratories
18 Papers
90 Citations
Diana Risin is an academic researcher from Wyle Laboratories. The author has contributed to research in topics: Cell culture & Biology. The author has an hindex of 11, co-authored 18 publications.
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Papers
Induction of three-dimensional assembly of human liver cells by simulated microgravity.
Vladimir I. Khaoustov,Gretchen J. Darlington,Humberto E. Soriano,Bhuvaneswari Krishnan,Diana Risin,Neal R. Pellis,Boris Yoffe +6 more
TL;DR: A simulated microgravity environment is conducive to maintaining long-term cultures of functional hepatocytes and will assist in developing improved protocols for autologous hepatocyte transplantation, gene therapy, and liver assist devices, and facilitate studies of liver regeneration and cell-to-cell interactions that occur in vivo.
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The current state of bone loss research: Data from spaceflight and microgravity simulators
Mamta Patel Nagaraja,Diana Risin +1 more
TL;DR: The objective of this review is to capture the most recent research on bone loss from spaceflights, bed rest and hindlimb unloading, and in vitro studies utilizing cellular models in clinostats to ensure the most rapid development of effective countermeasures.
110
Changes in gravity inhibit lymphocyte locomotion through type I collagen
Neal R. Pellis,Thomas J. Goodwin,Diana Risin,Bradley W. McIntyre,Roland P. Pizzini,David Cooper,Tacey L. Baker,Glenn F. Spaulding +7 more
TL;DR: In vitro investigations suggest that microgravity induces non-stress-related changes in cell function that may be critical to immunity, as well as characterize potential causes of microgravity-induced immunosuppression.
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Loss of Signal Transduction and Inhibition of Lymphocyte Locomotion in a Ground-Based Model of Microgravity
TL;DR: Direct activation of protein kinase C (PKC) with PMA was effective in restoring locomotion in MMG comparable to the normal levels seen in 1g cultures, suggesting that deoxyribonucleic acid replication is not essential for the restoration of locomotion.
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Cultures of human liver cells in simulated microgravity environment
Boris Yoffe,Gretchen J. Darlington,Humberto E. Soriano,Bhuvaneswari Krishnan,Diana Risin,Neal R. Pellis,Vladimir I. Khaoustov +6 more
TL;DR: A simulated microgravity environment is conducive for the establishment of long-term HLC cultures and allows the dissection of the mechanism of liver regeneration and cell-to-cell interactions that resembles in vivo conditions.
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