Diana L. Flasher
University of the Pacific (United States)
15 Papers
366 Citations
Diana L. Flasher is an academic researcher from University of the Pacific (United States). The author has contributed to research in topics: Liposome & Lipid bilayer fusion. The author has an hindex of 11, co-authored 15 publications. Previous affiliations of Diana L. Flasher include University of California, San Francisco & Chiron Corporation.
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Papers
Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells.
Nejat Düzgüneş,Elizabeth Pretzer,Sérgio Simões,Vladimir Slepushkin,Krystyna Konopka,Diana L. Flasher,Maria C. Pedroso de Lima +6 more
TL;DR: Liposomes can be used to facilitate the intracellular delivery of certain anti-HIV agents and to enhance their therapeutic effects, and these properties may be particularly advantageous in the development of novel macromolecular drugs.
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Treatment of intracellular Mycobacterium avium complex infection by free and liposome-encapsulated sparfloxacin.
TL;DR: This study investigated whether the fluoroquinolone sparfloxacin is effective in treating MAC infection in the murine macrophage-like cell line J774, and encapsulated in the membrane phase of multilamellar liposomes composed of phosphatidylglycerol-phosphatodylcholine-cholesterol.
Fusion activity and inactivation of influenza virus: kinetics of low pH-induced fusion with cultured cells.
Nejat Düzgüneş,M. C. Pedroso de Lima,Leonidas Stamatatos,Diana L. Flasher,D. Alford,D. S. Friend,S Nir +6 more
TL;DR: Although preincubation of the virus at acidic pH in the absence of target membranes almost completely inactivated the virus in its ability to fuse with erythrocyte ghosts, it reduced the extent of fusion with cultured cells by only 20 to 40%.
Treatment of Mycobacterium avium-intracellulare Complex Infection in Beige Mice with Free and Liposome-Encapsulated Streptomycin: Role of Liposome Type and Duration of Treatment
Nejat Düzgüneş,Dilip R. Ashtekar,Diana L. Flasher,Naheed Ghori,Robert J. Debs,Daniel S. Friend,Pattisapu R. J. Gangadharam +6 more
TL;DR: Observations suggest that liposome encapsulation not only targets streptomycin to infected cells but also increases the residual activity of the drug.
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Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus
Maria C. Pedroso de Lima,Maria C. Pedroso de Lima,João Ramalho-Santos,Diana L. Flasher,Vladimir Slepushkin,S Nir,S Nir,Nejat Düzgüneş,Nejat Düzgüneş +8 more
TL;DR: Results indicate that binding of influenza virus to sialic acid residues on the cell surface leads to rapid and extensive fusion and partially inhibits the low pH-induced viral inactivation.
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