Diana García-Moreno
University of Murcia
46 Papers
140 Citations
Diana García-Moreno is an academic researcher from University of Murcia. The author has contributed to research in topics: Biology & Zebrafish. The author has an hindex of 15, co-authored 34 publications. Previous affiliations of Diana García-Moreno include Carlos III Health Institute.
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Papers
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Sylwia D. Tyrkalska,Ana B. Pérez-Oliva,Lola Rodríguez-Ruiz,Francisco J. Martínez-Morcillo,Francisca Alcaraz-Pérez,Francisco J. Martínez-Navarro,Christophe Lachaud,Nouraiz Ahmed,Timm Schroeder,Irene Pardo-Sánchez,Sergio Candel,Azucena López-Muñoz,Avik Choudhuri,Avik Choudhuri,Marlies P. Rossmann,Marlies P. Rossmann,Leonard I. Zon,María L. Cayuela,Diana García-Moreno,Victoriano Mulero +19 more
TL;DR: It is reported that genetic or chemical manipulation of different inflammasome components altered the differentiation of hematopoietic stem and progenitor cells (HSPC) in zebrafish, indicating that the inflammaome plays a major role in the pathogenesis of neutrophilia and anemia of chronic diseases.
NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death.
Francisco J. Martínez-Morcillo,Joaquín Cantón-Sandoval,Francisco J. Martínez-Navarro,Isabel Cabas,Idoya Martínez-Vicente,Joy Armistead,Julia Hatzold,Azucena López-Muñoz,Teresa Martínez-Menchón,Raúl Corbalán-Vélez,Jesús Lacal,Matthias Hammerschmidt,José C. García-Borrón,Alfonsa García-Ayala,María L. Cayuela,Ana B. Pérez-Oliva,Diana García-Moreno,Victoriano Mulero +17 more
TL;DR: In this article, the rate-limiting enzyme in the salvage pathway of NAD+ biosynthesis, reduced oxidative stress, inflammation, and keratinocyte DNA damage, hyperproliferation, and cell death in zebrafish models of chronic skin inflammation, while all these effects were reversed by NAD+ supplementation.
A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients
Beatriz Bernal-Bermúdez,Alicia Martínez-López,Francisco J. Martínez-Morcillo,Sylwia D. Tyrkalska,Teresa Martínez-Menchón,Pablo Mesa-del-Castillo,María L. Cayuela,Victoriano Mulero,Diana García-Moreno +8 more
TL;DR: The development of a transgenic zebrafish model of Type I interferonopathy overexpressing ifih1 carrying the mutation p.Arg742His is reported, demonstrating the potential of this model to further understand AGS pathological mechanisms and to identify novel therapeutic drugs by HTS.
Identification of an Evolutionarily Conserved Ankyrin Domain-Containing Protein, Caiap, Which Regulates Inflammasome-Dependent Resistance to Bacterial Infection.
Sylwia D. Tyrkalska,Sergio Candel,Ana B. Pérez-Oliva,Ana Valera,Francisca Alcaraz-Pérez,Diana García-Moreno,María L. Cayuela,Victoriano Mulero +7 more
TL;DR: The results point to ANK domain-containing proteins as key inflammasome adaptors required for the stabilization of active caspase-1 in functionally stable, high molecular weight complexes.
The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation
Francisco J. Martínez-Navarro,Francisco J. Martínez-Morcillo,Azucena López-Muñoz,Irene Pardo-Sánchez,Teresa Martínez-Menchón,Raúl Corbalán-Vélez,María L. Cayuela,Ana B. Pérez-Oliva,Diana García-Moreno,Victoriano Mulero +9 more
TL;DR: Results of the study demonstrate that glycogen stores and G6pd fuel NADPH oxidase to promote skin inflammation, revealing novel targets for the treatment of skin inflammatory disorders.