Dian Li
Soochow University (Suzhou)
5 Papers
17 Citations
Dian Li is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Prodrug & Drug carrier. The author has an hindex of 5, co-authored 5 publications.
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Papers
Polymer–Doxorubicin Prodrug with Biocompatibility, pH Response, and Main Chain Breakability Prepared by Catalyst-Free Click Reaction
TL;DR: It turned out that the pH-responsive polymeric prodrug nanoparticles could be internalized into HeLa cells, release original DOX, and efficiently inhibit the proliferation of cancer cells.
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Efficient Click Synthesis of a Protonized and Reduction-Sensitive Amphiphilic Small-Molecule Prodrug Containing Camptothecin and Gemcitabine for a Drug Self-Delivery System.
TL;DR: This protonized and reduction-sensitive prodrug simultaneously binds both antitumor drugs and has good self-delivery behavior through the donor-acceptor interaction of H-bonding ligand, i.e. 1,2,3-triazole group provides a new method for the combined drug therapy.
34
Facile preparation of pH-responsive PEGylated prodrugs for activated intracellular drug delivery
TL;DR: The cytotoxicity and intracellular uptake assays revealed that the PEGylated acid-sensitive prodrugs could rapidly internalized by HeLa or HepG2 cells to release DOX and effectively inhibited the proliferation of the tumor cells, which have the potential for use in cancer therapy.
33
A twin-tailed tadpole-shaped amphiphilic copolymer of poly(ethylene glycol) and cyclic poly(ε-caprolactone): synthesis, self-assembly and biomedical applications
Yanyan Zhou,Lei Li,Wei Chen,Dian Li,Nianchen Zhou,Jinlin He,Peihong Ni,Zhengbiao Zhang,Xiulin Zhu +8 more
TL;DR: The in vitro cytotoxicities against L929 fibroblast cells and HeLa cells evaluated by MTT assays revealed that the copolymers, especially PEG-b-(c-PCL)-b-PEG and 2PEG- b-2PCL, exhibited favorable biocompatibility, which might be potentially used as nanoscale drug delivery systems.
21
One-Pot Synthesis of pH/Redox Responsive Polymeric Prodrug and Fabrication of Shell Cross-Linked Prodrug Micelles for Antitumor Drug Transportation.
TL;DR: A new kind of pH/redox responsive dynamic covalent SCL micelle, fabricated by self-assembly of a multifunctional polymeric prodrug, which can enhance the stability and prevent the drug from leaking in the body during blood circulation.