Di Gong
Sichuan University
11 Papers
22 Citations
Di Gong is an academic researcher from Sichuan University. The author has contributed to research in topics: Biology & Downregulation and upregulation. The author has an hindex of 6, co-authored 10 publications.
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Papers
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin
Kai Li,Chunfen Mo,Di Gong,Yan Chen,Zhao Huang,Yanyan Li,Jie Zhang,Lugang Huang,Yuan Li,Frances V. Fuller-Pace,Ping Lin,Yuquan Wei +11 more
TL;DR: Findings reveal a novel and important mechanism by which DDX17 contributes to acquired gefitinib resistance through exportin/importin-dependent cytoplasmic shuttling and followed by activation of β-catenin, andDDX17 inhibition may be a promising strategy to overcome acquired resistance of gefITinib in NSCLC patients.
47
ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma
Kai Li,Gang Zhao,Jie Ao,Di Gong,Jie Zhang,Yue Chen,Jun Li,Lugang Huang,Rong Xiang,Jiankun Hu,Ping Lin,Yuquan Wei +11 more
TL;DR: Mechanistically, it is demonstrated that ZNF32 overexpression suppresses the reactive oxygen species (ROS) accumulation and maintains mitochondrial membrane potential, leading to ATP, GSH and NADPH elevation and promoting HCC cell survival in response to suspension and the potential therapeutic value of ZNF 32 in HCC patients is suggested.
34
Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway.
Qianwen Zheng,Qin Li,Gang Zhao,Jie Zhang,Hang Yuan,Di Gong,Yafei Guo,Xinhua Liu,Kai Li,Ping Lin +9 more
TL;DR: An important mechanism by which alkannin induces cytotoxic autophagy and apoptosis is revealed by promoting ROS-mediated mitochondrial dysfunction and activation of the JNK pathway.
29
ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma.
Jun Li,Jun Li,Jie Ao,Kai Li,Jie Zhang,Yanyan Li,Le Zhang,Yuyan Wei,Di Gong,Junping Gao,Weiwei Tan,Lugang Huang,Lunxu Liu,Ping Lin,Yuquan Wei +14 more
TL;DR: ZNF32-associated target therapy is a potential novel adjuvant therapy that might effectively prevent the occurrence of multidrug resistance (MDR) during chemotherapy and improve the survival of patients with AC.
23
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage
Jie Zhang,Kai Li,Miao Yuan,Guizen Huang,Jie Ao,Haoze Tan,Yanyan Li,Di Gong,Jun Li,Lei Kang,Nini An,Fei Li,Ping Lin,Lugang Huang +13 more
TL;DR: It is reported for the first time that a high-fat diet impairs the reproductive system by decreasing IL1β and enhancing testosterone levels in mice-TIS, which is different from the effects in animals treated at immature stage.