12 Papers
2 Citations
Dhriti Sinha is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Dhriti Sinha include University of Texas at Austin & University of Texas Health Science Center at San Antonio.
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Papers
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
TL;DR: A model in which pneumococcus maintains high Pi transport in high and low Pi conditions that is required for optimal capsule biosynthesis is supported.
Polynucleotide phosphorylase promotes the stability and function of Hfq-binding sRNAs by degrading target mRNA-derived fragments.
TL;DR: It is reported that PNPase contributes to the degradation of specific short mRNA fragments, the majority of which bind Hfq and are derived from targets of sRNAs, and these mRNA-derived fragments accumulate in the absence of P NPase or its exoribonuclease activity and interact with PNPases.
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A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation
Tom Dendooven,Dhriti Sinha,Alzbeta Roeselová,Todd A. Cameron,Nicholas R. De Lay,Ben F. Luisi,Katarzyna J Bandyra +6 more
TL;DR: In this article, a ternary assembly formed by PNPase, the RNA chaperone Hfq, and sRNA is shown to boost sRNA stability in vitro.
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Poly(A) polymerase is required for RyhB sRNA stability and function in Escherichia coli
TL;DR: It is reported that poly(A) polymerase (PAP I), which promotes RNA degradation by exoribonucleases through the addition of poly( A) tails, has a crucial role in the regulation of gene expression by Hfq-dependent sRNAs.
Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis.
Dhriti Sinha,Dhriti Sinha,Jacob P Frick,Kristen Clemons,Malcolm E. Winkler,Nicholas R De Lay +5 more
TL;DR: In this article, the authors investigated the role of RNases in regulating bacterial virulence factors in the major human respiratory pathogen Streptococcus pneumoniae (pneumococcus) and found that RNase Y and PNPase are essential for pneumococcal pathogenesis.
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