Dewight Williams
University of Pennsylvania
11 Papers
55 Citations
Dewight Williams is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chemistry & Temozolomide. The author has an hindex of 11, co-authored 11 publications.
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Papers
Trans-mitochondrial coordination of cristae at regulated membrane junctions
Martin Picard,Meagan J. McManus,György Csordás,Péter Várnai,Gerald W. Dorn,Dewight Williams,György Hajnóczky,Douglas C. Wallace +7 more
TL;DR: It is reported that adjacent mitochondria exhibit coordination of inner mitochondrial membrane cristae at inter-mitochondrial junctions (IMJs) that may provide the structural basis to enhance the propagation of intracellular bioenergetic and apoptotic waves through mitochondrial networks within cells.
Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes.
Zhuo Wang,Zhuo Wang,Zhong Deng,Nadia Dahmane,Kevin Tsai,Pu Wang,Dewight Williams,Andrew V. Kossenkov,Louise C. Showe,Rugang Zhang,Qihong Huang,Jose R. Conejo-Garcia,Paul M. Lieberman +12 more
TL;DR: It is shown that noncoding telomere RNA transcripts [telomeric repeat-containing RNA (TERRA)] are secreted into the extracellular environment in exosome vesicle fractions, suggesting a previously unidentified extrinsic function for TERRA and a mechanism of communication between telomeres and innate immune signals in tissue and tumor microenvironments.
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Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins
Shaodong Zhang,Qi Xiao,Samuel E. Sherman,Adam Muncan,Andrea D. M. Ramos Vicente,Zhichun Wang,Daniel A. Hammer,Dewight Williams,Yingchao Chen,Darrin J. Pochan,Sabine Vértesy,Sabine André,Michael L. Klein,Hans-Joachim Gabius,Virgil Percec +14 more
TL;DR: The applicability of Janus-GDs to dissect structure-activity relationships between programmable cell surface models and human lectins in a highly sensitive and physiologically relevant manner is illustrated.
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Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients.
Cameron J. Koch,Robert A. Lustig,Xiang-Yang Yang,W. T. Jenkins,Ronald L. Wolf,Maria Martinez-Lage,Arati Desai,Dewight Williams,Sydney M. Evans +8 more
TL;DR: Preliminary data suggest that blood analysis for MVs from GB patients receiving CRT may be useful to distinguish TE/PsP from TP, and may add clarity to standard imaging for decision making in patients with equivocal imaging findings.
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Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients.
Sydney M. Evans,Mary E. Putt,Xiang-Yang Yang,Robert A. Lustig,Maria Martinez-Lage,Dewight Williams,Arati Desai,Ronald L. Wolf,Steven Brem,Cameron J. Koch +9 more
TL;DR: There is initial evidence that increases in Annexin V positive microvesicle levels during chemoradiation therapy are associated with earlier recurrence and shorter overall survival in newly diagnosed glioblastoma patients.
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