Devorah Olam
Hebrew University of Jerusalem
15 Papers
62 Citations
Devorah Olam is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Hepatocellular carcinoma & Internal medicine. The author has an hindex of 9, co-authored 13 publications.
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Papers
Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice.
Mark Katzenellenbogen,Lina Mizrahi,Orit Pappo,Naama Klopstock,Devorah Olam,Jasmine Jacob-Hirsch,Ninette Amariglio,Gideon Rechavi,Eytan Domany,Eithan Galun,Daniel Goldenberg +10 more
TL;DR: The Mdr2-KO mouse may serve as a model for β-catenin–negative subgroup of human HCCs characterized by low nuclear cyclin D1 levels in tumor cells and by down-regulation of multiple tumor suppressor genes.
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Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis in the Mdr2-Knockout Mice
Mark Katzenellenbogen,Orit Pappo,Hila Barash,Naama Klopstock,Lina Mizrahi,Devorah Olam,Jasmine Jacob-Hirsch,Ninette Amariglio,G. Rechavi,Leslie Ann Mitchell,Ron Kohen,Eytan Domany,Eithan Galun,Daniel Goldenberg +13 more
TL;DR: The data suggest that some of the adaptive mechanisms induced in the early stages of hepatic disease, which protect the liver from injury, could have an effect in hepatocarcinogenesis at later stages of the disease in this hepatocellular carcinoma model.
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Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice.
Mark Katzenellenbogen,Lina Mizrahi,Orit Pappo,Naama Klopstock,Devorah Olam,Hila Barash,Eytan Domany,Eithan Galun,Daniel Goldenberg +8 more
TL;DR: Both tannic acid and selenomethionine had partial chemopreventive effect on development of hepatocellular carcinoma in Mdr2-KO mice: they reduced the incidence of large tumor nodules at age 16 months.
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The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
Lika Gamaev,Lina Mizrahi,Tomer Friehmann,Nofar Rosenberg,Orit Pappo,Devorah Olam,Evelyne Zeira,Keren Bahar Halpern,Stefano Caruso,Jessica Zucman-Rossi,Jonathan H. Axelrod,Eithan Galun,Daniel Goldenberg +12 more
TL;DR: It is demonstrated that the lncRNA H19 is pro-oncogenic during the development of chronic inflammation-mediated HCC in the Mdr2-KO mouse model, mainly by increasing liver injury and decreasing hepatocyte polyploidy in young mice.
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The Sphingosine 1 Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway
Katia Beider,Evgenia Rosenberg,Hanna Bitner,Avichai Shimoni,Merav Leiba,Maya Koren-Michowitz,Elena Ribakovsky,Shiri Klein,Devorah Olam,Lola Weiss,Hanna Wald,Michal Abraham,Eithan Galun,Amnon Peled,Arnon Nagler +14 more
TL;DR: A cross-talk between the S1P and CXCR4 pathways in MM cells is identified and provides a preclinical rationale for the therapeutic application of FTY720 in combination with bortezomib in patients with MM.