Devin Saunders
Children's National Medical Center
11 Papers
15 Citations
Devin Saunders is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Immunotherapy & Immune system. The author has an hindex of 3, co-authored 9 publications.
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Papers
Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study
Amy B. Hont,C. Russell Cruz,Robert Ulrey,Barbara O’Brien,Maja Stanojevic,Anushree Datar,Shuroug Albihani,Devin Saunders,Ryo Hanajiri,Karuna Panchapakesan,Sam Darko,Payal Banerjee,Maria Fernanda Fortiz,Fahmida Hoq,Haili Lang,Yunfei Wang,Patrick J. Hanley,Jeffrey S. Dome,Catherine M. Bollard,Holly J. Meany +19 more
TL;DR: TAA-Ts safely induced disease stabilization, prolonged time to progression, and were associated with antigen spreading and a reduction in circulating tumor-associated antigen DNA levels in patients with relapsed/refractory solid tumors without lymphodepleting chemotherapy before infusion.
Medulloblastoma rendered susceptible to NK-cell attack by TGFß neutralization
C. Cruz,Allison B. Powell,Sridevi Yadavilli,S. Van Pelt,Devin Saunders,Rachel A. Burga,Shuroug Albihani,Elizabeth Williams,Patrick J. Hanley,Yanxin Pei,Eric Yvon,Eugene Hwang,Catherine M. Bollard,Javad Nazarian +13 more
TL;DR: CB NK cells expressing a dominant negative TGF-β receptor II (DNRII) by retroviral transduction may have a functional advantage over unmodified NK cells in the presence of T GF-β-rich MB, warranting further investigation as a novel therapeutic for the treatment of patients with high-risk medulloblastoma.
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DNA methylation accelerated age as captured by epigenetic clocks influences breast cancer risk
TL;DR: In this article , the authors synthesize the existing evidence on epigenetic clocks measurement of DNA methylation based accelerated age and breast cancer outcomes and demonstrate that DNA methylations accelerated age may provide key insights for tackling increasing rates of U.S. breast cancer incidence and overall disease disparities experienced by women from minoritized backgrounds.
Ex vivo expanded multi-antigen specific lymphocytes for the treatment of solid tumors.
Amy Houghtelin,C. Russell Cruz,Robert Ulrey,Barbara O’Brien,Maja Stanojevic,Shuroug Albihaini,Devin Saunders,Fahmida Hoq,Maria Fernanda Fortiz,Haili Lang,Patrick J. Hanley,Catherine M. Bollard,Holly J. Meany +12 more
TL;DR: A small number of patients with solid tumors refractory to standard therapies have poor prognoses, and most salvage therapies are toxic and ineffective, so antigen-specific T cell therapies offer a prom...
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