Devanjan Sikder
University of Texas Southwestern Medical Center
16 Papers
127 Citations
Devanjan Sikder is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Transcription factor & Chromatin immunoprecipitation. The author has an hindex of 13, co-authored 14 publications.
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Papers
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
William Renthal,Arvind Kumar,Guanghua Xiao,Matthew Wilkinson,Herbert E. Covington,Ian Maze,Devanjan Sikder,Alfred J. Robison,Quincey LaPlant,Quincey LaPlant,David M. Dietz,Scott J. Russo,Vincent Vialou,Sumana Chakravarty,Thomas Kodadek,Ashley Stack,Mohammed Kabbaj,Eric J. Nestler,Eric J. Nestler +18 more
TL;DR: This work used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration, and reveals several interesting principles of gene regulation by cocaine.
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Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Suprabha Pulipparacharuvil,William Renthal,Carly F. Hale,Makoto Taniguchi,Guanghua Xiao,Arvind Kumar,Scott J. Russo,Devanjan Sikder,Colleen M. Dewey,Maya M. Davis,Paul Greengard,Angus C. Nairn,Angus C. Nairn,Eric J. Nestler,Christopher W. Cowan +14 more
TL;DR: It is suggested that reducing MEF2 activity in the NAc in vivo is required for the cocaine-induced increases in dendritic spine density and increasing spine density may be a compensatory mechanism to limit long-lasting maladaptive behavioral responses to cocaine.
290
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.
Matthew Wilkinson,Guanghua Xiao,Arvind Kumar,Arvind Kumar,Quincey LaPlant,William Renthal,Devanjan Sikder,Thomas Kodadek,Eric J. Nestler +8 more
TL;DR: The results demonstrate that chronic defeat stress causes widespread and long-lasting changes in gene regulation, including alterations in repressive histone methylation and in phospho-CREB (cAMP response element-binding protein) binding, in the mouse nucleus accumbens (NAc), a key brain reward region implicated in depression.
266
Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
Amy E. Lovett-Racke,Anne E. Rocchini,Judy Choy,Sara C. Northrop,Rehana Z. Hussain,Robert B. Ratts,Devanjan Sikder,Michael K. Racke +7 more
TL;DR: T-bet was shown to bind the IFNgamma and STAT1 promoters, but did not regulate the IL-12/STAT4 pathway, which means T-bet may be a target for therapeutics for Th1-mediated diseases.
199
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival
Todd J. Page,Devanjan Sikder,Longlong Yang,Linda J. Pluta,Russell D. Wolfinger,Thomas Kodadek,Russell S. Thomas +6 more
TL;DR: Analysis of the extended HSF1 signaling network following siRNA knockdown showed enrichment in a variety of categories related to protein folding, anti-apoptosis, RNA splicing, ubiquitinylation and others, highlighting a complex transcriptional program regulated directly and indirectly by HSF 1.
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