Detlef Trost
University of Bonn
7 Papers
92 Citations
Detlef Trost is an academic researcher from University of Bonn. The author has contributed to research in topics: DiGeorge syndrome & Messenger RNA. The author has an hindex of 7, co-authored 7 publications.
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Papers
KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas
Antje Brockschmidt,Detlef Trost,Heike Peterziel,Katrin Zimmermann,Marion Ehrler,Henriette Grassmann,Philipp Niclas Pfenning,Anke Waha,Dirk Wohlleber,Felix F. Brockschmidt,Manfred Jugold,Alexander Hoischen,Claudia Kalla,Andreas Waha,Gerald Seifert,Percy A. Knolle,Eicke Latz,Eicke Latz,Volkmar Hans,Volkmar Hans,Wolfgang Wick,Wolfgang Wick,Alexander Pfeifer,Peter Angel,Ruthild G. Weber,Ruthild G. Weber +25 more
TL;DR: The frequently deleted KIAA1797 gene encodes a novel focal adhesion complex protein with tumour suppressor function in gliomas, which is named 'focadhesin'.
Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors.
Detlef Trost,Marion Ehrler,Rolf Fimmers,Jörg Felsberg,Michael Sabel,Lutz Kirsch,Johannes Schramm,Otmar D. Wiestler,Guido Reifenberger,Ruthild G. Weber +9 more
TL;DR: Several independent genomic markers of shorter survival in patients with oligodendroglial tumors are identified, and molecular diagnostic testing, which is usually restricted to 1p/19q deletion analysis, may need to be refined by additionally assessing the prognostically unfavorable genomic aberrations identified.
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New trends in chromosomal investigation in children with cardiovascular malformations.
Ruth Schellberg,Gesa Schwanitz,Lutz Grävinghoff,Rolf Kallenberg,Detlef Trost,Ruth Raff,Walter Wiebe +6 more
TL;DR: The approach to genetic investigation in three phases makes it possible to detect a high rate of pathologic karyotypes in patients with congenital cardiovascular malformations, thus guaranteeing more effective genetic counselling of the families, and a more precise prognosis for the patient.
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Angeborene kardiovaskulare fehlbildungen und chromosomale mikrodeletionen in 22q11.2
TL;DR: In patients with congenital c-v and associated malformations of dysmorphism microdeletion diagnosis of 22q11.2 by FISH is indicated in addition to conventional cytogenetic testing.
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Array-CGH in unclear syndromic nephropathies identifies a microdeletion in Xq22.3-q23
Alexander Hoischen,Christina Landwehr,Sarah Kabisch,Xiao-Qi Ding,Detlef Trost,Gerhard Stropahl,Marianne Wigger,Bernhard Radlwimmer,Ruthild G. Weber,Dieter Haffner +9 more
TL;DR: In one of ten patients with unclear syndromic nephropathies, a previously undescribed contiguous gene syndrome is identified at Xq22.3-q23.3, which contains the X-linked Alport syndrome gene COL4A5, the MR genes FACL4 and PAK3, and parts of theX-chromosomal lissencephaly gene DCX associated with double cortex formation in girls, MR, and epilepsy.
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