Desirae L. Deskins
Vanderbilt University Medical Center
6 Papers
Desirae L. Deskins is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Mesenchymal stem cell & Cell therapy. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Desirae L. Deskins include United States Department of Veterans Affairs & Vanderbilt University.
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Papers
A physiological role for connective tissue growth factor in early wound healing
Maria P. Alfaro,Desirae L. Deskins,Meredith Wallus,Jayasri DasGupta,Jeffrey M. Davidson,Jeffrey M. Davidson,Lillian B. Nanney,Michelle A. Guney,Maureen Gannon,Pampee P. Young,Pampee P. Young +10 more
TL;DR: It is demonstrated that when CTGF expression is confined to early tissue repair, it serves a pro-reparative role and the potential of MSC-derived paracrine modulators to enhance tissue repair.
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Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs).
Sarika Saraswati,Desirae L. Deskins,Desirae L. Deskins,Ginger E. Holt,Pampee P. Young,Pampee P. Young +5 more
TL;DR: Using an in vivo model of granulation tissue formation, it is demonstrated that pyrvinium enhanced long‐term MSC engraftment and Pyrvinium‐treated MSC‐generated granulation tissues demonstrated less ectopic differentiation into bone or cartilage.
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The polyvinyl alcohol sponge model implantation.
TL;DR: The preparation, implantation and retrieval of PVA sponge disks are described in a mouse model of wound healing, an ideal model for many studies and has been utilized to investigate tumor angiogenesis, drug delivery and stem cell survival and engraftment.
Human Mesenchymal Stromal Cells: Identifying Assays to Predict Potency for Therapeutic Selection
Desirae L. Deskins,Dikshya Bastakoty,Sarika Saraswati,Andrew A. Shinar,Ginger E. Holt,Pampee P. Young,Pampee P. Young +6 more
TL;DR: It is found that high performance in a combination of the in vitro tests accurately predicted which lines functioned well in vivo, suggesting that reliable and reproducible in vitro assays may be used to measure the functional potential of MSCs for therapeutic use.
Membrane versus Soluble Isoforms of TNF-α Exert Opposing Effects on Tumor Growth and Survival of Tumor-Associated Myeloid Cells
TL;DR: It is shown for the first time that membrane and soluble isoforms have diametrically opposing effects on both tumor growth and myeloid content and that there are significant differences in the role of different TNF-α isoforms in tumor progression and the bioavailability of each isoform may distinctly regulate tumor progression.