Derrick P. McCarthy
Northwestern University
19 Papers
17 Citations
Derrick P. McCarthy is an academic researcher from Northwestern University. The author has contributed to research in topics: Immune tolerance & T cell. The author has an hindex of 15, co-authored 18 publications.
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Papers
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis
Daniel R. Getts,Aaron Martin,Derrick P. McCarthy,Rachael L. Terry,Zoe Hunter,Woon Teck Yap,Meghann Teague Getts,Michael A. Pleiss,Xunrong Luo,Nicholas J. C. King,Lonnie D. Shea,Stephen D. Miller +11 more
TL;DR: It is shown that antigen-decorated microparticles (500-nm diameter) induce long-term T-cell tolerance in mice with relapsing experimental autoimmune encephalomyelitis, highlighting the potential for using microp articles to target natural apoptotic clearance pathways to inactivate pathogenic T cells and halt the disease process in autoimmunity.
Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
Daniel R. Getts,Daniel R. Getts,Rachael L. Terry,Rachael L. Terry,Meghann Teague Getts,Celine Deffrasnes,Marcus Müller,Caryn van Vreden,Thomas M. Ashhurst,Belal Chami,Derrick P. McCarthy,Huiling Wu,Jin Ma,Aaron Martin,Lonnie D. Shae,Paul K. Witting,Geoffrey S. Kansas,Joachim E. Kühn,Wali Hafezi,Iain L. Campbell,David J. Reilly,Jana M. Say,Louise J. Brown,Melanie Y. White,Stuart J. Cordwell,Steven J. Chadban,Edward B. Thorp,Shisan Bao,Stephen D. Miller,Nicholas J. C. King +29 more
TL;DR: It is shown that infused negatively charged, immune-modifying microparticles, derived from polystyrene, microdiamonds, or biodegradable poly(lactic-co-glycolic) acid, were taken up by inflammatory monocytes, in an opsonin-independent fashion, via the macrophage receptor with collagenous structure (MARCO).
A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease.
Zoe Hunter,Derrick P. McCarthy,Woon Teck Yap,Christopher T. Harp,Daniel R. Getts,Lonnie D. Shea,Stephen D. Miller +6 more
TL;DR: The ability of biodegradable poly(lactic-co-glycolic acid) (PLG) nanoparticles to function as a safe, cost-effective, and highly efficient alternative to cellular carriers for the induction of antigen-specific T cell tolerance is shown.
282
Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10–Producing Splenic Macrophages and Maintained by T Regulatory Cells
Daniel R. Getts,Danielle M. Turley,Cassandra E. Smith,Christopher T. Harp,Derrick P. McCarthy,Emma M. Feeney,Meghann Teague Getts,Aaron Martin,Xunrong Luo,Rachael L. Terry,Nicholas J. C. King,Stephen D. Miller +11 more
TL;DR: It is shown for the first time that tolerance results from the synergistic effects of two distinct mechanisms, PD-L1–dependent T cell-intrinsic unresponsiveness and the activation of T regulatory cells, which indicate that Ag-SP tolerance recapitulates how tolerance is normally maintained in the hematopoietic compartment.
197
Oligodendrocyte death results in immune-mediated CNS demyelination
TL;DR: It is indicated that oligodendrocyte death is sufficient to trigger an adaptive autoimmune response against myelin, suggesting that a similar process can occur in the pathogenesis of multiple sclerosis.