Derek Smith
Codexis
38 Papers
153 Citations
Derek Smith is an academic researcher from Codexis. The author has contributed to research in topics: Imine & Proline. The author has an hindex of 8, co-authored 38 publications. Previous affiliations of Derek Smith include Novartis.
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Papers
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction.
Feng Xu,Birgit Kosjek,Fabien L. Cabirol,Haibin Chen,Richard Desmond,Jeonghan Park,Anupam Gohel,Steven J. Collier,Derek Smith,Zhuqing Liu,Jacob M. Janey,John Y. L. Chung,Oscar Alvizo +12 more
TL;DR: An efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high-pH environment was described by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.
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Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase
Naga K. Modukuru,Joly Sukumaran,Steven J. Collier,Ann Shu Chan,Anupam Gohel,Gjalt W. Huisman,Raquel Keledjian,Karthik Narayanaswamy,Scott J. Novick,S. M. Palanivel,Derek Smith,Zhang Wei,Brian Wong,Wan Lin Yeo,David Entwistle +14 more
TL;DR: This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbzepine).
38
Patent
Synthesis of prazole compounds
Yong Koy Bong,Michael D. Clay,Steven J. Collier,Benjamin Mijts,Michael Vogel,Xiyun Zhang,Jun Zhu,Jovana Nazor,Derek Smith,Shiwei Song +9 more
- 08 Dec 2010
TL;DR: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polyPEptides, and methods of using the poly peptides.
34
Patent
Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
Haibin Chen,Steven J. Collier,Jovana Nazor,Joly Sukumaran,Derek Smith,Jeffrey C. Moore,Gregory Hughes,Jacob Janey,Gjalt W. Huisman,Scott J. Novick,Nicholas J. Agard,Oscar Alvizo,Gregory A. Cope,Wan Lin Yeo,Stefanie Ng Minor +14 more
- 09 May 2013
TL;DR: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reduction enzymes, host cells capable of expressing the engineered reductases, and methods of using these engineered PU with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds as mentioned in this paper.
29
Patent
Biocatalysts and methods for hydroxylation of chemical compounds
Haibin Chen,Yong Koy Bong,Fabien L. Cabirol,Anupam Gohel,Li Tao,Jeffrey C. Moore,Quintanar-Audelo Martina,Hong Yang,Steven J. Collier,Derek Smith +9 more
- 07 May 2013
TL;DR: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxymethylated compounds, polynucleotides encoding the engineered Proline Hydroxylases as discussed by the authors.
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