Deranda B. Lester
University of Memphis
27 Papers
94 Citations
Deranda B. Lester is an academic researcher from University of Memphis. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 10, co-authored 24 publications. Previous affiliations of Deranda B. Lester include St. Jude Children's Research Hospital.
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Papers
Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders
TL;DR: In this article, the authors examined neurological and psychopathological conditions associated with dysfunctions in the interaction of acetylcholine and dopamine and conventional and new pharmacological approaches to treat these disorders.
Evolution of Deep Brain Stimulation: Human Electrometer and Smart Devices Supporting the Next Generation of Therapy
Kendall H. Lee,Charles D. Blaha,Paul A. Garris,Pedram Mohseni,April E. Horne,Kevin E. Bennet,Filippo Agnesi,Jonathan M. Bledsoe,Deranda B. Lester,Christopher J. Kimble,Hoon Ki Min,Young Bo Kim,Zang-Hee Cho +12 more
TL;DR: This hypothesis states that therapeutic benefit is provided, at least in part, by activation of surviving nigrostriatal dopaminergic neurons, subsequent striatal dopamine release, and resumption of striatal target cell control by dopamine.
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Risky decision-making predicts dopamine release dynamics in nucleus accumbens shell
TL;DR: In vivo fixed potential amperometry in male Long-Evans rats observed a positive correlation between medial forebrain bundle-evoked dopamine release in the NACs and risky decision-making, suggesting that risk-taking is associated with elevated dopamine sensitivity.
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Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice.
Lene S. Schmidt,Anthony D. Miller,Deranda B. Lester,Cecilie Bay-Richter,Christina Schülein,Henriette Frikke-Schmidt,Jiirgen Wess,Charles D. Blaha,David P.D. Woldbye,Anders Fink-Jensen,Gitta Wörtwein +10 more
TL;DR: It is shown for the first time that amphetamine-induced hyperactivity and dopamine release as well as amphetamine sensitization are enhanced in mice lacking the M5 receptor, which supports the concept that the M 5 receptor modulates effects of addictive drugs.
Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release.
TL;DR: It is suggested that acetylcholine and ionotropic glutamate receptors influence rapid dopaminergic activity and thus the communication of behaviorally relevant information from ventral tegmental area dopamine cells to forebrain areas.
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