Dequina A. Nicholas
University of California, San Diego
29 Papers
53 Citations
Dequina A. Nicholas is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 22 publications. Previous affiliations of Dequina A. Nicholas include Boston University & Loma Linda University.
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Papers
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath,Madhur Agrawal,Grace McCambridge,Dequina A. Nicholas,Hatice Hasturk,Jing Liu,Kai Jiang,Rui Liu,Zhenheng Guo,Jude T. Deeney,Caroline M. Apovian,Jennifer E. Snyder-Cappione,Gregory S. Hawk,Rebecca Fleeman,Riley M.F. Pihl,Katherine L. Thompson,Anna C. Belkina,Licong Cui,Licong Cui,Elizabeth A. Proctor,Philip A. Kern,Barbara S. Nikolajczyk +21 more
TL;DR: It is concluded that metformin improves autophagy and mitochondrial function largely in parallel to ameliorate a newly defined inflammaging profile that echoes inflammation in diabetes.
435
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity.
Jacques C. Mbongue,Dequina A. Nicholas,Timothy W. Torrez,Nan-Sun Kim,Nan-Sun Kim,Anthony Firek,William H. R. Langridge +6 more
TL;DR: How IDO-mediated catabolism of tryptophan can modulate the immune system to arrest inflammation, suppress immunity to cancer and inhibit allergy, autoimmunity and the rejection of transplanted tissues is assessed.
317
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Dequina A. Nicholas,Elizabeth A. Proctor,Madhur Agrawal,Anna C. Belkina,Stephen C. Van Nostrand,Leena Panneerseelan-Bharath,Albert R. Jones,Forum Raval,Blanche C. Ip,Min Zhu,Jose M. Cacicedo,Chloe Habib,Nestor Sainz-Rueda,Leah Persky,Patrick G. Sullivan,Barbara E. Corkey,Caroline M. Apovian,Philip A. Kern,Douglas A. Lauffenburger,Barbara S. Nikolajczyk +19 more
TL;DR: New data show long-chain acylcarnitine combines with compromised β oxidation to promote disease-predictive inflammation in human T2D, and shows glycolysis was not critical for Th17 cytokines.
131
AB toxins: a paradigm switch from deadly to desirable.
TL;DR: Comparisons and differences in the structure and function of bacterial and plant AB toxins that underlie their toxicity and their exceptional properties as immunomodulators for stimulating immune responses against infectious disease and for immune suppression of organ-specific autoimmunity are examined.
112
Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β
Dequina A. Nicholas,Kangling Zhang,Christopher Hung,Shane Glasgow,Aruni Wilson Aruni,Juli Unternaehrer,Kimberly J. Payne,William H. R. Langridge,Marino De Leon +8 more
TL;DR: The experiments demonstrate for the first time that PA activation of TLR4 occurs in response to direct molecular interactions between PA and MD-2, suggesting a likely molecular mechanism for PA induction of pro-inflammatory immune responses in human dendritic cells expressingTLR4.