Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in the Indian subcontinent, not only for health care but also for the preservation of food and as a yellow dye for textiles. Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. Since the time of Ayurveda (1900 Bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life".

Curcumin: The Indian solid gold

https://digital.library.unt.edu/ark:/67531/metadc284540/m2/1/high_res_d/1-s2.0-S0304419X13000644-main.pdf

Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a direction in treating diseases and an essential strategy for the development of new drugs. In the past few decades, the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks. In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small molecules, peptides, and antibodies, hoping to provide some guidance to the design of novel drugs targeting PPIs in the future.

/pdf/recent-advances-in-the-development-of-protein-protein-58lq971vul.pdf

Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials.

Role of curcumin in cancer therapy

Life or death: neuroprotective and anticancer effects of quercetin.

Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.

Relationship between flavonoid structure and inhibition of farnesyl protein transferase

Inhibitory activity of diarylheptanoids on farnesyl protein transferase.

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Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.

Relationship between flavonoid structure and inhibition of farnesyl protein transferase

Inhibitory activity of diarylheptanoids on farnesyl protein transferase.