Dennis Litty
Goethe University Frankfurt
11 Papers
7 Citations
Dennis Litty is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Chemistry & ATP synthase. The author has an hindex of 2, co-authored 5 publications.
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Papers
Butyrate production in the acetogen Eubacterium limosum is dependent on the carbon and energy source.
Dennis Litty,Volker Müller +1 more
TL;DR: In this article, a detailed study on growth of E. limosum KIST612 on different carbon and energy sources with the goal, to find other substrates that lead to butyrate formation was performed.
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One substrate, many fates: different ways of methanol utilization in the acetogen Acetobacterium woodii.
TL;DR: In this paper , the authors used genetic methods to identify mtaBC2A as the methanol specific methyltransferase system of Acetobacterium woodii and showed that when fed in combination with other electron sources such as H2 + CO2 or CO, methanoline was converted Rnf-independently and the methyl group was condensed with CO to build acetate.
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Biosynthesis of butyrate from methanol and carbon monoxide by recombinant Acetobacterium woodii
TL;DR: In this paper , the butyrate production operon from a related acetogen, Eubacterium callanderi KIST612, was introduced into Acetobacterium woodii and showed a stable production of butyrates from methanol.
Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ
Amaravadhi Harikishore,Chui-Fann Wong,Priya Ragunathan,Dennis Litty,Volker Müller,Gerhard Grüber +5 more
TL;DR: In this article, an eight-featured α-533-545 peptide pharmacophore was developed, followed by database screening, molecular docking, and pose selection, resulting in eleven hit molecules.
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GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876.
Priya Ragunathan,Pearly Shuyi Ng,Wee Han Poh,Dennis Litty,Nitin Pal Kalia,Simon Larsson,Amaravadhi Harikishore,Scott A Rice,Philip W Ingham,Volker Müller,Garrett C. Moraski,Marvin J Miller,Thomas Dick,Kevin Pethe,Gerhard Grüber +14 more
TL;DR: It is reported that GaMF1.39 depletes cellular ATP formation by targeting the mycobacterial F-ATP synthase without affecting proton coupling or oxygen consumption and may add value to a compound combination targeting oxidative phosphorylation for tuberculosis treatment.
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