Dennis Lex
RWTH Aachen University
8 Papers
39 Citations
Dennis Lex is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Lung injury & Virus. The author has an hindex of 6, co-authored 8 publications.
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Papers
One-hit Models of Ventilator-induced Lung Injury: Benign Inflammation versus Inflammation as a By-product.
Dennis Lex,Stefan Uhlig +1 more
TL;DR: It is suggested that biotrauma—when defined as a ventilation-induced and inflammation-dependent hypoxemia—is difficult to study in murine one-hit models of ventilation, at least not within 7 h.
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Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection
Seiki Fujiwara,Midori Hoshizaki,Yu Ichida,Dennis Lex,Etsushi Kuroda,Ken Ishii,Shigeyuki Magi,Mariko Okada,Hiroyuki Takao,Masahiro Gandou,Hirotaka Imai,Ryujiro Hara,Herbert Herzog,Akihiko Yoshimura,Hitoshi Okamura,Josef M. Penninger,Josef M. Penninger,Arthur S. Slutsky,Stefan Uhlig,Keiji Kuba,Yumiko Imai +20 more
TL;DR: Direct regulation of the NPY–Y1R–SOCS3 pathway on phagocytes may act as a fine-tuner of an innate immune response to virus infection, which could be a therapeutic target for lethal influenza virus infection.
17
18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome.
Stefanie Preuß,Julia Scheiermann,Sabrina Stadelmann,Friede D. Omam,Supandi Winoto-Morbach,Dennis Lex,Philipp von Bismarck,Sabine Adam-Klages,Friederike Knerlich-Lukoschus,Daniela Wesch,Janka Held-Feindt,Stefan Uhlig,Stefan Schütze,Martin Krause +13 more
TL;DR: It is concluded that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects.
17
Modulation of antigen-induced responses by serotonin and prostaglandin E2 via EP1 and EP4 receptors in the peripheral rat lung
Anna-Karin Larsson-Callerfelt,Sven-Erik Dahlén,Anna-Rebekka Kühl,Dennis Lex,Stefan Uhlig,Christian Martin +5 more
TL;DR: Data indicate that PGE(2) is the main prostanoid involved in the early allergic airway response in the rat lung, and appears to act both as a primary mediator of antigen-induced airway contraction via the EP(4) receptor and as a downstream modulator of serotonin-induced bronchoconstriction via theEP(1) receptor.
13
Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine.
Stefanie Preuß,Friede D. Omam,Julia Scheiermann,Sabrina Stadelmann,Supandi Winoto-Morbach,Philipp von Bismarck,Sabine Adam-Klages,Friederike Knerlich-Lukoschus,Dennis Lex,Daniela Wesch,Janka Held-Feindt,Stefan Uhlig,Stefan Schütze,Martin Krause +13 more
TL;DR: Exogenous surfactant “fortified” by PIP2, a naturally occurring surfactants component, improves lung function by topical suppression of aSMase, providing a potential treatment concept for neonates with hypoxemic respiratory failure.
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